A Receptor-Independent Effect of Estrone Sulfate on the hERG Channel

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概要

• 論文の詳細を見る

• We recently reported that physiological concentrations of 17β-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K+ currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogens have the same effect as that of 17β-estradiol, we investigated receptor-independent effects of estrone, estrone 3-sulfate, and estriol on hERG currents in patch-clamped estrogen-negative HEK293 cells. Only estrone 3-sulfate partially suppressed hERG currents in a receptor-independent manner by modifying the gating. The concentration-dependence of estrone 3-sulfate revealed that physiological levels of circulating estrone 3-sulfate can modulate hERG currents to the maximal extent in both women and men at any age.

• 社団法人 日本薬理学会の論文
• 2009-01-20

著者

• SUZUKI Takeshi

  Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute

• SASANO Tetsuo

  Department of Cardiovascular Disease, Yokohama Red Cross Hospital

• Sasano Tetsuo

  Dep. Of Bio-informational Pharmacology Medical Res. Inst. Tokyo Medical And Dental Univ. Jpn

• Sasano Tetsuo

  Department Of Bio-informational Pharmacology Medical Research Institute Tokyo Medical And Dental Uni

• Kurokawa Junko

  Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental U

• Furukawa Tetsushi

  Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental U

• KAIHARA Asami

  Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental U

• Kaihara Asami

  Department Of Bio-informational Pharmacology Medical Research Institute Tokyo Medical And Dental Uni

• KAKUSAKA Shoko

  Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental U

• ASAYAMA Mahoko

  Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental U

• Kakusaka Shoko

  Department Of Bio-informational Pharmacology Medical Research Institute Tokyo Medical And Dental Uni

• Asayama Mahoko

  Department Of Bio-informational Pharmacology Medical Research Institute Tokyo Medical And Dental Uni

• Kurokawa Junko

  Department Of Bio-informational Pharmacology Medical Research Institute Tokyo Medical And Dental Uni

• Furukawa Tetsushi

  Department Of Bio-informational Pharmacology Medical Research Institute Tokyo Medical And Dental Uni

• Kurokawa Junko

  Department Of Bio-informational Pharmacology Medical Research Institute Tokyo Medical And Dental Uni

• Kurokawa Junko

  Department Of Bio-informational Pharmacology Medical Research Institute Tokyo Medical And Dental Uni

• Kaihara Asami

  Department Of Bio-informational Pharmacology Medical Research Institute Tokyo Medical And Dental Uni

• Suzuki Takeshi

  Division Of Basic Biological Sciences Faculty Of Pharmacy Keio University

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