Potentiation of the Response of GABA_A Receptors by Bangladeshi Medicinal Plants

スポンサーリンク

概要

• 論文の詳細を見る

• As part of the search for new sources of mental health supplements, alcohol extracts of 11 Bangladeshi medicinal fruits and plants were investigated for neuropharmacological effects in mice and on ionotropic γ-aminobutyric acid receptors (GABAA receptors). The extracts of S. caseolaris, T. bellirica, S. cumini, and T. arjuna significantly potentiated the GABA-induced response of GABAA receptors expressed in Xenopus oocytes, though the extracts alone induced no response. In mice, administration of these extracts prolonged pentobarbital-induced sleeping time. Potentiation of GABAA receptor response reportedly generates anxiolytic, sedative, sleep-inducing and anesthetic activities in the human brain. Thus, these extracts may have potential regarding the development of a supplement with tranquilizing and sleepinducing effects that is beneficial for mental health.

• 2009-05-01

著者

• Yamamoto Makie

  Applied Molecular Bioscience Graduate School Of Medicine Yamaguchi University

• Ahmed Firoj

  Exercise And Health Science Faculty Of Education Yamaguchi University

• Tan Nobusuke

  Exercise And Health Science Faculty Of Education Yamaguchi University

• Aoshima Hitoshi

  Applied Molecular Bioscience Graduate School Of Medicine Yamaguchi University

• Hossain Sheikh

  Biotechnology And Genetic Engineering Discipline Khulna University

• MUBASSARA Sanzida

  Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University

• Mubassara Sanzida

  Applied Molecular Bioscience Graduate School Of Medicine Yamaguchi University

関連論文

• Total Phenolic Content, Antioxidative, Anti-amylase, Anti-glucosidase, and Antihistamine Release Activities of Bangladeshi Fruits
• Potentiation of the Response of GABA_A Receptors by Bangladeshi Medicinal Plants

スポンサーリンク