Ganoderic Acid Me Inhibits Tumor Invasion Through Down-Regulating Matrix Metalloproteinases 2/9 Gene Expression
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概要
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The effect of ganoderic acid Me (GA-Me), which was purified from the fermentation mycelia of the traditional Chinese medicinal mushroom Ganoderma lucidum as reported (Tang W, Gu TY, Zhong JJ. Biochem Eng J. 2006;32:205–210), on anti-invasion was investigated. Wound healing assay indicated that GA-Me inhibited cell migration of 95-D, a human highly metastatic lung tumor cell line, in dose- and time-dependent manners. Results of cell aggregation and adhesion assays showed that GA-Me promoted cell homotypic aggregation and inhibited cell adherence to extracellular matrix (ECM). In addition, GA-Me suppressed matrix metalloproteinases 2/9 (MMP2/9) gene expressions at both mRNA and protein levels in 95-D cells according to qRT-PCR and Western blotting, respectively. The results demonstrated that GA-Me effectively inhibited tumor invasion, and it might act as a new MMP2/9 inhibitor for anti-metastasis treatment of carcinoma cells.
- 2008-10-20
著者
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Zhong Jian-Jiang
Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences and Biotechno
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Liu Jian-wen
State Key Laboratory Of Bioreactor Engineering East China University Of Science And Technology
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CHEN Nian-Hong
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
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Zhong Jian-jiang
Key Laboratory Of Microbial Metabolism (ministry Of Education) School Of Life Sciences And Biotechno
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Zhong Jian-jiang
Key Laboratory Of Microbial Metabolism Ministry Of Education College Of Life Science & Biotechno
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Chen Nian-hong
State Key Laboratory Of Bioreactor Engineering East China University Of Science And Technology
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- Ganoderic Acid Me Inhibits Tumor Invasion Through Down-Regulating Matrix Metalloproteinases 2/9 Gene Expression
- FM-P11 Comparison of individual ganoderic acids production and identification of differentially expressed genes between liquid static culture and shaking culture of Ganoderma lucidum(Section VIII Fermentation and Microbial Technology)