Decreased Expression of Angiotensin II Type 1 and Type 2 Receptors in the Brain After Long-Term Administration of Antihypertensive Drugs in Stroke-Prone Spontaneously Hypertensive Rat
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概要
- 論文の詳細を見る
The present study examined the levels of Angiotensin II type 1 receptor (AT1) and type 2 receptor (AT2) in the brain stem and cerebral cortex of the stroke-prone spontaneously hypertensive rat (SHR-sp) after long-term treatment with three types of antihypertensive drugs: valsartan, enalapril, and amlodipine. In both tissues, expression of the AT1 was decreased by administration of each drug. Expression of the AT2 was decreased in the cerebral cortex by drug administration, but did not change in the brain stem. This study may contribute to elucidating the relationship between AT1 and AT2 expressions and the effect of antihypertensive drugs in SHR-sp brain.
- 社団法人 日本薬理学会の論文
- 2008-04-20
著者
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Ishikawa K
Surgery Division Arita Gastrointestinal Hospital
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SUGAHARA KOBAYASHI
Department of Pharmacology, Nihon University School of Medicine
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TAKAHASHI Yasuo
Division of Genomic Epidemiology and Clinical Trials, Nihon University School of Medicine
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ISHIKAWA Koichi
Department of Pharmacology, Nihon University School of Medicine
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Nishida Yayoi
Division Of Genomic Epidemiology And Clinical Trials Nihon University School Of Medicine
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Takahashi Yasuo
Fourth Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Ishikawa Koichi
Department Of Pharmacology Nihon University School Of Medicine
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Sugahara Kobayashi
Department Of Pharmacology Nihon University School Of Medicine
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Asai Satoshi
Division Of Genomic Epidemiology And Clinical Trials Nihon University School Of Medicine
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Ishikawa K
Department Of Pharmacology Nihon University School Of Medicine
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ISHIKAWA Kouichi
Department of Pharmacology, Nihon University School of Medicine
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Takahashi Yasuo
Department Of Internal Medicine Higashi Sapporo Hospital
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Takahashi Yasuo
Division Of Genomic Epidemiology And Clinical Trials Nihon University School Of Medicine
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Takahashi Yasuo
Division Of Genomic Epidemiology And Clinical Trials Advanced Medical Research Center
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Asai Satoshi
Division Of Genomic Epidemiology And Clinical Trials Advanced Medical Research Center
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Takahashi Yasuo
Division Of Genetic And Genomic Medicine Advanced Medical Research Center Nihon University School Of
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Asai Satoshi
Division Of Genetic And Genomic Medicine Advanced Medical Research Center Nihon University School Of Medicine
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Sugahara-Kobayashi Megumi
Department of Pharmacology, Nihon University School of Medicine
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