The Potential of Amniotic Membrane/Amnion-Derived Cells for Regeneration of Various Tissues
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概要
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Regenerative medicine is a new field based on the use of stem cells to generate biological substitutes and improve tissue functions, restoring damaged tissue with high proliferability and differentiability. It is of interest as a potential alternative to complicated tissue/organ transplantation. Recently, amnion-derived cells have been reported to have multipotent differentiation ability, and these cells have attracted attention as a cell source for cell-transplantation therapy. The amnion possesses considerable advantageous characteristics: the isolated cells can differentiate into all three germ layers; they have low immunogenicity and anti-inflammatory functions; and they do not require the sacrifice of human embryos for their isolation, thus avoiding the current controversies associated with the use of human embryonic stem cells. Moreover, we developed human amniotic cell-sheets using a novel culture surface coated with a noncytotoxic, temperature-responsive elastic protein-based polymer. We also generated a “hyper-dry-amnion”, which has already been applied clinically in the ophthalmological field. Compared to cryopreserved fresh amnion, “hyper-dry-amnion” is easy to handle and has started to bring good results to patients. These materials from the amnion are also expected to open a new field in tissue engineering. Thus, amnion, which had been discarded after parturition, has started to be appreciated as an attractive material in the field of regenerative medicine. In this review, the most recent and relevant clinical and experimental data about the use of amniotic membrane and cells derived from it are described.
- 社団法人 日本薬理学会の論文
- 2007-11-20
著者
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OKABE Motonori
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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Yoshida Toshiko
Department of Adult Health Nursing, School of Nursing, Miyagi University
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Okabe Motonori
Department Of Regenerative Medicine University Of Toyama Graduate School Of Medicine And Pharmaceuti
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Okabe Motonori
Department Of Anatomy 2 Faculty Of Medicine Toyama Medical And Pharmaceutical University
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NIKAIDO Toshio
Department of Organ Regeneration, Institutes of Organ Transplants, Reconstructive Medicine and Tissu
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Nikaido Toshio
Department Of Regenerative Medicine University Of Toyama Graduate School Of Medicine And Pharmaceuti
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Nikaido Toshio
Department Of Gynecology And Obstetrics Shinshu University School Of Medicine
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TODA Ayaka
Department of Regenerative Medicine, University of Toyama Graduate School of Medicine and Pharmaceut
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Toda Ayaka
Department Of Regenerative Medicine University Of Toyama Graduate School Of Medicine And Pharmaceuti
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Yoshida Toshiko
Department Of Regenerative Medicine University Of Toyama Graduate School Of Medicine And Pharmaceuti
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Yoshida Toshiko
Department Of Adult Health Nursing School Of Nursing Miyagi University
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