Gene expression of PROSC (proline synthetase co-transcribed) in related to cytosine arabinoside sensitivity in human leukemia

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概要

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• We examined the PCR differential display analysis of cDNA clones from human leukemia K562 cell line and those of cytosine arabinoside (ara-C) resistant K562 cells. We compared mRNA samples obtained from the two cell lines by amplified restriction fragment length polymorphism (AFLP)-based mRNA fingerprinting; 40 bands were observed in each lane of a gel, and the screened results were five independent, isolated clones. In this study, we isolated the proline synthetase co-transcribed (PROSC) gene from an ara-C sensitive K562 cell line as one of the clones. RNase protection assay and RT-PCR analysis revealed increased expression of PROSC gene in K562 sensitive cells compared with that of ara-C resistant K562 cells. The PROSC gene product is likely a soluble cytoplasmic protein, but its function remains unclear. Thus, the PROSC gene might be related to the sensitivity to ara-C in human leukemia and downregulated in resistant cells.

• 2008-09-01

著者

• FUNATO TADAO

  Department of Laboratory Science, School of Health Sciences, Faculty of Medicines, Kyoto University

• Takeda Mayu

  Department Of Healthcare Economics And Quality Management Tohoku Fukushi University

• Funato Tadao

  Department Of Healthcare Economics And Quality Management Tohoku Fukushi University

• SAITO Kuniaki

  Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine

• Funato Tadao

  Department Of Clinical Laboratory And Medicine School Of Medicine Tohoku University

• Saito Kuniaki

  Department Of Laboratory Science School Of Health Science Faculty Of Medicine Kyoto University

• FUJIMAKI Shin-ich

  Department of Infection Control and Laboratory Diagnostics, Tohoku University School of Medicine

• Saito Kuniaki

  Department Of Informative Clinical Medicine Gifu University Graduate School Of Medicine

• Fujimaki Shin-ich

  Department Of Infection Control And Laboratory Diagnostics Tohoku University School Of Medicine

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