Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells
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概要
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An animal model in which the human immune system can be reconstituted is necessary to study acquired immunity in vivo. We report here a novel model, the NOD/SCID/JAK3null mouse, for the human immune system's development. Newborn mice transplanted with human cord blood CD34+ cells intrahepatically, developed human T and B cells, and myeloid and plasmacytoid dendritic cells. The T and B cells had a naïve to memory phenotype, and included plasma cells. The human acquired immune system can be reconstituted from CD34+ cells in NOD/SCID/JAK3null mice. This model is a powerful tool for the study of human immunity.
- 2008-12-15
著者
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SAITO Takashi
Laboratory for Cell Signaling, Riken Research Center for Allergy and Immunology
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ITO Takaaki
Department of Pathology. Yokohama City University School of Medicine
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Okada Seiji
Division Of Hematopoiesis Center For Aids Research Kumamoto University
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Ito Takaaki
東京大学 医学系研究科泌尿器科
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Suzu Shinya
Division Of Hematopoiesis Center For Aids Research
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Harada Hideki
Division Of Hematopoiesis Center For Aids Research Kumamoto University
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Ito Takaaki
Department Of Dermatology Hyogo College Of Medicine
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Saito Takashi
Laboratory For Cell Signaling Riken Research Center For Allergy And Immunology
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Saito Takashi
Laboratory For Cell Signaling Riken Center For Allergy And Immunology
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Saito Takashi
Department Of Patho-physiology-periodontal Science Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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Ito Takaaki
Department of Chemical System Engineering, The University of Tokyo
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