Fundamental Studies on Electrokinetic Chromatography with PEGylated Phospholipid Micelles
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概要
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In this study, micelles prepared from distearoylphosphatidylethanolamine with covalently attached poly(ethylene) glycol) (PEG) of molecular weight 2000 (DSPE-PEG-2000) were employed in micellar electrokinetic chromatography (MEKC) as pseudostationary phases. Since DSPE-PEG-2000 contains long hydrophobic alkyl chains, an anionic phosphate group, and hydrophilic PEG chains, the prepared micelles are expected to provide a characteristic retention behavior for both neutral and ionic compounds. As a typical example, a baseline separation of phenol and 2-naphthol was successfully achieved by using the DSPE-PEG-2000 micelles as a background electrolyte for MEKC; such success clearly shows that the micelles can retain electrically neutral compounds. The MEKC separations of anionic and cationic compounds with a DSPE-PEG-2000 micellar solution and the enantioseparation of binaphthyl compounds with mixed micelles containing bile salt are also discussed.
- 2008-01-10
著者
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Kitagawa Fumihiko
Department Of Material Chemistry Graduate School Of Engineering Kyoto University
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Kitagawa Fumihiko
Department Of Joint Research Laboratory Of Clinical Medicine Fujita Health University Hospital
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Otsuka Koji
Department Of Internal Medicine Iii Osaka Medical College
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Onoue Satomi
School Of Pharmaceutical Sciences University Of Shizuoka
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HASEGAWA Takayuki
Department of Material Chemistry, Graduate School of Engineering, Kyoto University
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TAJI Hiromi
Nagoya Laboratories, Pfizer Japan Inc.
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TSUDA Yoshiko
Nagoya Laboratories, Pfizer Japan Inc.
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Otsuka Koji
Department Of Electronic Engineering Faculty Of Engineering University Of Tokyo
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Taji Hiromi
Nagoya Laboratories Pfizer Japan Inc.
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Tsuda Yoshiko
Nagoya Laboratories Pfizer Japan Inc.
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Hasegawa Takayuki
Department Of Chemistry Graduate School Of Science Osaka City University
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Onoue Satomi
School Of Pharmaceutical Science University Of Shizuoka
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Hasegawa Takayuki
Department Of Material Chemistry Graduate School Of Engineering Kyoto University
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Hasegawa Takayuki
Department Of Applied Physics Graduate School Of Engineering Osaka City University
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Kitagawa Fumihiko
Department Of Frontier Materials Chemistry Graduate School Of Science And Technology Hirosaki University
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