Design of Constant Supersaturation Cooling Crystallization of a Pharmaceutical : A Simple Approach
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概要
- 論文の詳細を見る
This paper describes a simple method for designing a batch cooling crystallization of a pharmaceutical under constant supersaturation. The simple model assumes that crystal growth is the predominant mechanism during the crystallization and requires only two parameters, crystal growth rate constant and solubility. Both parameters are functions of temperature and are obtained simultaneously by conducting a single experiment with multiple-step cooling. The model was validated through additional natural cooling and controlled cooling crystallization experiments. Finally, it was demonstrated experimentally that the supersaturation throughout the crystallization process was effectively kept constant by applying the cooling trajectory predicted by the model.
- 社団法人 化学工学会の論文
- 2007-01-01
著者
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HANAKI Keigo
Department of Applied Chemistry, School of Science and Engineering, Waseda University
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HIRASAWA Izumi
Department of Applied Chemistry, School of Science and Engineering, Waseda University
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Hanaki Keigo
Department Of Applied Chemistry School Of Science And Engineering Waseda University
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KATO Yoshiaki
Process Research, Process R&D, Laboratories for Technology Development, Banyu Pharmaceutical Co., Lt
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Hirasawa Izumi
Department Of Applied Chemistry School Of Science And Engineering Waseda University
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NONOYAMA Nobuaki
Process Research, Banyu Pharmaceutical Co., Ltd.
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YABUKI Yasuaki
Process Research, Banyu Pharmaceutical Co., Ltd.
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Yabuki Yasuaki
Process Research Banyu Pharmaceutical Co. Ltd.
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Yabuki Yasuaki
Process R&d Laboratories For Technology Development Banyu Pharmaceutical Co. Ltd.
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Hirasawa Izumi
Department Of Applied Chemistry Graduate School Of Advanced Science And Engineering Waseda Universit
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Nonoyama Nobuaki
Process Research Banyu Pharmaceutical Co. Ltd.
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Kato Yoshiaki
Process Research Banyu Pharmaceutical Co. Ltd.
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Kato Yoshiaki
Process R&d Laboratories For Technology Development Banyu Pharmaceutical Co. Ltd.
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Hanaki Keigo
Dep. Of Applied Chemistry School Of Sci. And Engineering Waseda Univ.
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