The Mechanism of Endothelium-Independent Relaxation Induced by the Wine Polyphenol Resveratrol in Human Internal Mammary Artery

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概要

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• Resveratrol, a stilbene polyphenol found in grapes and red wine, produces vasorelaxation in both endothelium-dependent and endothelium-independent manners. The mechanisms by which resveratrol causes vasodilatation are uncertain. The aim of this study was to investigate the mechanism(s) of endothelium-independent resveratrol-induced vasorelaxation in human internal mammary artery (HIMA) obtained from male patients undergoing coronary artery bypass surgery and to clarify the contribution of different K+ channel subtypes in resveratrol action in this blood vessel. HIMA rings without endothelium were precontracted with phenylephrine. Resveratrol induced a concentration-dependent relaxation of the HIMA. A highly selective blocker of ATP-sensitive K+ channels, glibenclamide, as well as nonselective blockers of Ca2+-sensitive K+ channels, tetraethylammonium and charybdotoxin, did not block resveratrol-induced relaxation of HIMA rings. 4-Aminopyridine (4-AP), non selective blocker of voltage-gated K+ (KV) channels, and margatoxin that inhibits KV1.2, KV1.3, and KV1.6 channels abolished relaxation of HIMA rings induced by resveratrol. In conclusion, we have shown that resveratrol potently relaxed HIMA rings with denuded endothelium. It seems that 4-AP- and margatoxin-sensitive K+ channels located in smooth muscle of HIMA mediated this relaxation.

• 社団法人 日本薬理学会の論文
• 2006-05-20

著者

• DJUKANOVIC Bosko

  Institute of Cardiovascular Diseases "Dedinje", Belgrade

• Novalovie Aleksandra

  Department Of Pharmacology Faculty Of Pharmacy University Of Belgrade

• Gojkovic-bukarica Ljiljana

  Department Of Clinical Pharmacology Pharmacology And Toxicology Faculty Of Medicine University Of Be

• Perie Miodrag

  Institute For Cardiovascular Diseases "dedinje

• Nezic Dusan

  Institute For Cardiovascular Diseases "dedinje

• NOVAKOVIC Aleksandra

  Department of Pharmacology, Faculty of Pharmacy, University of Belgrade

• HEINLE Helmut

  Institute of Physiology, University Tubingen

• PERIC Miodrag

  Institute for Cardiovascular Diseases "Dedinje"

• MARKOVIC-LIPKOVSKI Jasmina

  Institute of Pathology, Faculty of Medicine, University of Belgrade

• Markovic-lipkovski Jasmina

  Institute Of Pathology Faculty Of Medicine University Of Belgrade

• Djukanovic Bosko

  Institute For Cardiovascular Diseases "dedinje

関連論文

• Differential Antivasoconstrictor Effects of Levcromakalim and Rilmakalim on the Isolated Human Mammary Artery and Saphenous Vein
• A Role of Ion Channels in the Endothelium-Independent Relaxation of Rat Mesenteric Artery Induced by Resveratrol
• Potassium Channel Opener Pinacidil Induces Relaxation of the Isolated Human Radial Artery
• The Mechanism of Endothelium-Independent Relaxation Induced by the Wine Polyphenol Resveratrol in Human Internal Mammary Artery
• Analysis of Vasoreactivity of Isolated Human Radial Artery

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