Differential Antivasoconstrictor Effects of Levcromakalim and Rilmakalim on the Isolated Human Mammary Artery and Saphenous Vein

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概要

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• It is well established that spasm of an arterial and venous graft conduit may occur during harvesting or after coronary artery bypass grafting (CABG). The antivasoconstrictor effect of levcromakalim and rilmakalim, K+ channel openers (KCOs), was studied in isolated human internal mammary artery (HIMA) and human saphenous vein (HSV) prepared for CABG. HIMA and HSV rings were contracted by electrical field stimulation (EFS, 20 Hz ) or with exogenous noradrenaline (NA). Levcromakalim induced a concentration-dependent and equipotent inhibition of contraction of HIMA and HSV preconstricted by EFS and exogenoulsy applied NA, while rilmakalim produced a stronger inhibition of EFS- than NA-evoked contractions. Glibenclamide, a selective ATP-sensitive K+ channel (KATP channel) blocker, significantly antagonized levcromakalim-induced inhibition of EFS- and NA-evoked contractions, as well as rilmakalim-induced inhibiton of EFS-evoked contractions on HIMA and HSV. However, glibenclamide failed to antagonize rilmakalim-induced inhibition of NA-evoked contractions. The results suggest that the antivasoconstrictor effect of levcromakalim occurs postsynapticaly by the opening KATP channels in the vascular smooth muscle cells. They also suggest that the effect of rilmakalim on EFS-evoked contractions involves KATP channels located pre-synaptically. However, the mechanism by which rilmakalim inhibits NA-evoked contraction seems to be KATP channel independent and warrants further elucidation.

• 社団法人 日本薬理学会の論文
• 2003-06-01

著者

• Japundzic‐zigon N

  Univ. Belgrade Belgrade Zzz

• Saijio Zoran

  Institute Of Cardiovascular Diseases "dedinje" Belgrade

• NOVALOVIE Aleksandra

  Department of Pharmacology, Faculty of Pharmacy, University of Belgrade

• GOJKOVIC-BUKARICA Ljiljana

  Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine, University of

• BELESLIN-COKIE Bojana

  Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine, University of

• JAPUNDZIC-ZIGON Nina

  Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine, University of

• NEZIO Dusan

  Institute of Cardiovascular Diseases "Dedinje", Belgrade

• PERIE Miodrag

  Institute of Cardiovascular Diseases "Dedinje", Belgrade

• DJUKANOVIC Bosko

  Institute of Cardiovascular Diseases "Dedinje", Belgrade

• KAZIC Tomislax

  Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine, University of

• Nezic Dusan

  Inst. For Cardiovascular Diseases “dedinje" Serbia And Montenegro

• Kazic Tomislax

  Department Of Clinical Pharmacology Pharmacology And Toxicology School Of Medicine University Of Bel

• Novalovie Aleksandra

  Department Of Pharmacology Faculty Of Pharmacy University Of Belgrade

• Gojkovic-bukarica Ljiljana

  Department Of Clinical Pharmacology Pharmacology And Toxicology Faculty Of Medicine University Of Be

• Perie Miodrag

  Institute For Cardiovascular Diseases "dedinje

• Beleslin-cokie Bojana

  Department Of Clinical Pharmacology Pharmacology And Toxicology School Of Medicine University Of Bel

• NOVAKOVIC Aleksandra

  Department of Pharmacology, Faculty of Pharmacy, University of Belgrade

• Djukanovic Bosko

  Inst. For Cardiovascular Diseases “dedinje" Serbia And Montenegro

• Djukanovic Bosko

  Institute For Cardiovascular Diseases "dedinje

• Beleslin-Cokic Bojana

  Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine, University of Belgrade

関連論文

• Differential Antivasoconstrictor Effects of Levcromakalim and Rilmakalim on the Isolated Human Mammary Artery and Saphenous Vein
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• The Mechanism of Endothelium-Independent Relaxation Induced by the Wine Polyphenol Resveratrol in Human Internal Mammary Artery
• Analysis of Vasoreactivity of Isolated Human Radial Artery

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