X線結晶構造に基づくヒト Factor VIIa/Tissue Factor 選択的阻害機構の解明
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概要
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Factor VIIa/tissue factor is a key serine protease for initiation of blood coagulation. It is seen as promising target for the developing new anticoagulant drugs. X-ray crystal structures of human factor VIIa/tissue factor in complex with peptide mimetic inhibitors revealed important interactions for the selective inhibition of factor VIIa/tissue factor. These observations should provide some important information for a design of new factor VIIa selective inhibitors.
- 日本結晶学会の論文
- 2006-04-28