Determination of Urinary Phenolic Metabolites from Rats Treated with 1,2,3- and 1,3,5- Trimethylbenzenes

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Trimethylbenzene (TMB) is widely used as a solvent in the print and paint industries, and for products such as paint and varnish. Hence it causes environmental contamination not only in work places but also inside houses. Toluene and xylene are regarded as 'safe replacements' for benzene, due to the well-known finding that these less methyl-substituted benzenes are oxidized principally at a methyl substituent without substantial aromatic ring oxidation during in vivo metabolism. Although toxicological data on TMB are not abundant, some critical toxicities have been reported such as genotoxicity of TMB and haematotoxicity of 1, 2, 3-TMB. These data strongly suggest that TMB has 'benzene-like' toxicities. It is therefore necessary to obtain information on ring oxidation during metabolism of TMB. We describe here urinary excretion of phenolic metabolites in rats administered 1, 2, 3- and 1, 3, 5-TMBs, as a first investigation on ring oxidative metabolism of TMB. Materials and Methods 3, 4, 5- and 2, 4, 6-trimethylphenols (TMPs) were purchased from Wako Chemicals Inc. (Kyoto, Japan).
社団法人日本産業衛生学会の論文