Diphasic Effects of Astragalus membranaceus BUNGE (Leguminosae) on Vascular Tone in Rat Thoracic Aorta(Pharmacognosy)
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概要
- 論文の詳細を見る
This study was designed to investigate the effects of the aqueous ethanol extract of Astragalus membranaceus BUNGE (Leguminosae) on rat thoracic aorta. Isometric tension was recorded in response to drugs in organ bath. In endothelium-intact aortic rings, A. membranaceus extract induced a significant dose-dependent relaxation of the rings precontracted by phenylephrine, which could be inhibited by preincubation with L-N(ω)-nitro-arginine methyl ester or methylthioninium chloride. In endothelium-denuded ones, the extract could dose-dependently relax the rings contracted by phenylephrine, not by KCl; and it could also attenuate contractile response to phenylephrine, not to caffeine or phorbol-12, 13-diacetate in Ca^<2+>-free medium; but it failed to affect the CaCl_2-induced enhancement of contractile response to phenylephrine in Ca^<2+>-free medium. These results indicate that nitric oxide signaling and Ca^<2+>-handling pathway are involved in the A. membranaceus extract-induced vasodilatation.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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Qiu Li
Department Of Cardiology The First Affiliated Hospital College Of Medicine Zhejiang University
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Hu Shen
Department Of Cardiology The First Affiliated Hospital College Of Medicine Zhejiang University:e-ins
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Bian Ka
Department Of Integrative Biology And Pharmacology The University Of Texas-houston Medical School:e-
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Qiu Li-Hong
Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University
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Zhang Bi-Qi
Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University
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Sun Jian
Department Of Cardiology The First Affiliated Hospital College Of Medicine Zhejiang University
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Zhang Bi
Department Of Cardiology The First Affiliated Hospital College Of Medicine Zhejiang University
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SHAN Qi
Department of Physiology, College of Medicine, Zhejiang University
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XIA Qiang
Department of Physiology, College of Medicine, Zhejiang University
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Shan Qi
Department Of Physiology College Of Medicine Zhejiang University
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Hu Shen-Jiang
Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University
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