Antispasmodic Activity of Fractions and Cynaropicrin from Cynara scolymus on Guinea-Pig Ileum(Pharmacology)
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概要
- 論文の詳細を見る
This study describes the antispasmodic activity of some fractions and cynaropicrin, a sesquiterpene lactone from Cynara scolymus, cultivated in Brazil, against guinea-pig ileum contracted by acetylcholine. The dichloromethane fraction showed the most promising biological effects, with an IC_<50> of 0.93 (0.49-1.77) mg/ml. Its main active component, the sesquiterpene lactone cynaropicrin, exhibited potent activity, with IC_<50> of 0.065 (0.049-0.086) mg/ml, being about 14-fold more active than dichloromethane fraction and having similar potency to that of papaverine, a well-known antispasmodic agent. The results confirm the popular use of artichoke for the treatment of gastrointestinal disturbances, and encourage new studies on this compound, in order to obtain new antispasmodic agents.
- 公益社団法人日本薬学会の論文
- 2005-05-01
著者
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MONACHE Franco
Centro Chimica dei Recettori del C.N.R., Universita Cattolica
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Monache Franco
Centro Chimica Dei Recettori Del C.n.r. Universita Cattolica
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Monache Franco
Centro Chimica Recettori Istituto De Chimica Universitta Cattolica Del Sacro Cuore
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Yunes Rosendo
Curso De Pos-graduacao Em Quimica Universidade Federal De Santa Catarina (ufsc)
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Yunes Rosendo
Curso De Pos-graduacao Em Quimica Federal University Of Santa Catarina (ufsc)
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CECHINEL FILHO
Programa de Mestrado em Ciencias Farmaceuticas, Nucleo de Investigacoes Quimico-Farmaceticas (NIQFAR
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Cechinel Filho
Programa De Mestrado Em Ciencias Farmaceuticas E Nucleo De Investigacoes Quimico-farmaceuticas (niqf
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EMENDORFER Fernanda
Programa de Mestrado em Ciencias Farmaceuticas e Nucleo de Investigacoes Quimico-Farmaceuticas (NIQF
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EMENDORFER Fabiane
Programa de Mestrado em Ciencias Farmaceuticas e Nucleo de Investigacoes Quimico-Farmaceuticas (NIQF
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BELLATO Fernanda
Programa de Mestrado em Ciencias Farmaceuticas e Nucleo de Investigacoes Quimico-Farmaceuticas (NIQF
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NOLDIN Vania
Programa de Mestrado em Ciencias Farmaceuticas e Nucleo de Investigacoes Quimico-Farmaceuticas (NIQF
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CARDOZO Alcibia
Department of Patology, Federal University of Santa Catarina
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Noldin Vania
Programa De Mestrado Em Ciencias Farmaceuticas E Nucleo De Investigacoes Quimico-farmaceuticas (niqf
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Cardozo Alcibia
Department Of Patology Federal University Of Santa Catarina
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Bellato Fernanda
Programa De Mestrado Em Ciencias Farmaceuticas E Nucleo De Investigacoes Quimico-farmaceuticas (niqf
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Emendorfer Fernanda
Programa De Mestrado Em Ciencias Farmaceuticas E Nucleo De Investigacoes Quimico-farmaceuticas (niqf
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