Chemoprevention of N-Nitrosodiethylamine Induced Phenobarbitol Promoted Liver Tumors in Rat by Extract of Indigofera aspalathoides(Pharmacology)
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概要
- 論文の詳細を見る
The chemopreventive effect of ethanol extract of Indigofera aspalathoides (EIA) on N-nitrosodiethylamine (DEN, 200 mg/kg)-induced experimental liver tumor was investigated in male Wistar rats. Oral administration of ethanol extract of Indigofera aspalathoides (250 mg/kg) effectively suppressed liver tumor induced with DEN as revealed by decrease in the levels of extend of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP), lipid peroxidase (LPO), glutathione peroxidase (Gpx) and glutathione 5-transferase (GST) with a concomitant increase in enzymatic antioxidant (superoxide dismutase and catalase) levels when compared to those in liver tumor bearing rats. The histopathological changes of liver sample were compared with respective control. Our results show a significant chemopreventive effect of EIA against DEN induced liver tumor.
- 公益社団法人日本薬学会の論文
- 2005-02-01
著者
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Chodon Dechen
Department of Medical Biochemistry, Dr. A L Mudaliar Post Graduate Institute of Basic Medical Scienc
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SAKTHISEKARAN Dhanapal
Department of Medical Biochemistry, University of Madras
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Chodon Dechen
Department Of Medical Biochemistry Dr. A L Mudaliar Post Graduate Institute Of Basic Medical Science
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Chodon Dechen
Department Of Medical Biochemistry Dr. Alm Post-graduate Institute Of Basic Medical Sciences Univers
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Murugesh N
Madurai Medical Coll. Tamil Nadu Ind
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RAJKAPOOR Balasubramanian
Department of Pharmacology, Vinayaka Mission's College of Pharmacy
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MURUGESH Narayanan
Institute of Pharmacology, Madurai Medical College
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Sakthisekaran Dhanapal
Department Of Medical Biochemistry Alm Postgraduate Institute Of Basic Medical Sciences University O
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Sakthisekaran Dhanapal
Department Of Medical Biochemistry Dr. Alm Post-graduate Institute Of Basic Medical Sciences Univers
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Rajkapoor B
Vinayaka Mission's Coll. Of Pharmacy Tamil Nadu Ind
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Rajkapoor Balasubramanian
Department Of Pharmacology Vel's College Of Pharmacy
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Murugesh Narayanan
Institute Of Pharmacology Madurai Medical College
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