Protective Effect of (-)-Epigallocatechin Gallate on Acute Experimental Colitis

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概要

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• We studied the ameliorative effect of (-)-epigallocatechin gallate (EGCG) on inflammatory bowel disease (IBD) induced by ethanolic 2,4,6-trinitrobenzene sulfonic acid (TNBS) in male 7-week-old rats. Intestinal lesions were associated with macroscopic damage score and measured as increase in myeloperoxidase (MPO) activity in mucosa. Pretreatment with EGCG (30 mg/kg daily i.g. for 10 days) significantly reduced macroscopic damage score, inhibited MPO activity and enhanced superoxide dismutase activity. These observations confirmed that EGCG can ameliorate acute experimental colitis by suppression of superoxide generation from colonic tissue.

• 2005-06-01

著者

• Hasegawa Noboru

  岐阜女子大学 家政学部健康栄養学

• Hasegawa Noboru

  Department Of Applied Physics Faculty Of Engineering Osaka University

• Mochizuki Miyako

  Department of Nutrition and Food Science, Gifu Women's University

• Mochizuki Miyako

  岐阜女子大学 家政学部健康栄養学

• Mochizuki Miyako

  Department Of Health And Nutrition Faculty Of Home Economics Gifu Women's University

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