Detection of Bis (diphenylarsine) oxide, Diphenylarsinic Acid and Phenylarsonic Acid, Compounds Probably Derived from Chemical Warfare Agents, in Drinking Well Water

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概要

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• The inhabitants living in a specific region of Kizaki area in Kamisu-town. Ibaraki Prefecture exhibited uncommon clinical central nervous system symptoms. A graphite furnace atomic absorption spectrophotometer detected markedly elevated concentration of arsenic (4.5 ppm) in their drinking well water. Further investigation using HPLC, GC/MS and HPLC/ICP/MS demonstrated that the structures of the arsenic were bis(diphenylarsine)oxide (BDPAO), diphenylarsinic acid (DPAA) and phenylarsonic acid (PAA), compounds that can be derived from the chemical warfare agents, diphenylchloroarsine (DA) and diphenylcyanoarsine (DC). The predominant form of the arsenic compound in the well water was DPAA (maximum 15 ppm), so that it was calculated that the inhabitants ingested 11-30 mg of DPAA daily. This is the first report of inhabitants that were injured by drinking well water contaminated with organic arsenic compounds that were likely derived from chemical weapons.

• 公益社団法人日本薬学会の論文
• 2005-04-01

著者

• Tamaoka Akira

  筑波大学 臨床医学系内科学(神経病学)

• Tamaoka Akira

  University Of Tsukuba 11 Tennodai

• Tamaoka Akira

  University Of Tsukuba

• DOY Mikio

  Ibaraki Prefectural Institute of Public Health

• Nakamura Miki

  Ibaraki Prefectural Institute Of Public Health

• Ishizaki Mutsuo

  Ibaraki Prefectural Institute of Public Health

• Yanaoka Tomoko

  Ibaraki Prefectural Institute of Public Health

• Hakuta Tadao

  Ibaraki Prefectural Institute of Public Health

• Ueno Seiichi

  Ibaraki Prefectural Institute of Public Health

• Komuro Michihiko

  Ibaraki Prefectural Institute of Public Health

• Shibata Miyako

  Ibaraki Prefectural Institute of Public Health

• Kitamura Tatsumi

  Ibaraki Prefectural Institute of Public Health

• Honda Akira

  Ibaraki Prefectural Institute of Public Health

• Ishii Kazuhiro

  University of Tsukuba, 11 Tennodai

• Shimojo Nobuhiro

  University of Tsukuba, 11 Tennodai

• Ogata Tsuyoshi

  Itako Health Center of Ibaraki prefecture

• Nagasawa Eiko

  Chemicals Evaluation and Research Institute

• Hanaoka Shigeyuki

  Chemicals Evaluation and Research Institute

• Doy Mikio

  Ibaraki Prefectural Central Hospital

• Ueno Seiichi

  Ibaraki Prefectural Hygienic Laboratory

• Ishizaki Mutsuo

  Dep. Of Health Pharmacy Yokohama Coll. Of Pharmacy

• Ishizaki Mutsuo

  Ibaraki Hygienic Laboratory

• Ishii Kazuhiro

  筑波大学 臨床医学系

• Ishii Kazuhiro

  University of Tsukuba

• Shimojo Nobuhiro

  University of Tsukuba

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