ESI/MS Studies on Macrolide Antibiotics Phosphorylated by an Extract of an Erythromycin Resistant-Escherichia coli
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概要
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Two macrolide antibiotics, clarithromycin and roxithromycin, have recently entered the market and are now in frequent clinical use. These antibiotics were inactivated by an inactivating enzyme, macrolide 2′-phosphotransferase [MPH(2′)I], extracted from highly erythromycin-resistant Escherichia coli, and the reaction products were analyzed by ESI-MS. It was demonstrated that the 2′-phosphate derivatives of these macrolides could be detected by analysis of the mixture of MPH(2′)I and adenosine 5′-triphosphate after only a simple sample pretreatment with the addition of 3% acetic acid into water-methanol (1 : 1, v/v).
- 1996-04-20
著者
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Yamamoto Keiko
Department Of Geophysics Graduate School Of Science Kyoto University Kyoto Japan
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Shida Yasuo
Department Of Engineering Ms Laboratory Tokyo University Of Pharmacy And Life Sciences
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Shida Yasuo
Department Of Chemical Analysis School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Yamamoto Koshi
Department Of Earth And Planetary Sciences Faculty Of Science Kobe University
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FUKUZAWA Motoko
Department of Chemical Analysis, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Yamamoto Keiko
Department Of Basic Allied Medicine School Of Health Sciences Gunma University
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Fukuzawa Motoko
Department Of Chemical Analysis School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Yamamoto Keiko
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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O'hara Koji
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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