ウサギ頬粘膜癌(VX2 癌)における脈管神経への影響に関する実験的研究

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In this study, tumor blood vessels, lymph vessels and peripheral nerve fibers were examined during the proliferation of VX2 carcinoma of the buccal mucosa in domestic rabbits, and have a research on histopathological and neurohistological. VX2 carcinoma of domestic rabbit is an original tumor that has been carried for years transplanted in the thigh muscle of donors in our department. Tumor tissue (non-necrotic) was removed, weighed, and ground in a glass homogenizer. A suspension of 500, 000 tumor cells per ml of 5 percent calf serum in Eagle's Minimum Essential Medium was prepared. VX2 carcinoma cells were implanted into rabbit's buccal mucosa, and the domestic rabbits were divided into four groups. Histopathological and neurohistological observations were performed in 5, 10, 15 and 20 days after transplantation. The results were as follows : 1. Growth of a transplanted VX2 carcinoma in domestic rabbits was accompanied by an increase and invasion into the tissue of the buccal mucosa. 2. In the experiments, lymph vessels invasion was observed early in the growth of the transplanted tumor. These changes became significant at 10 days after transplantation. 3. The invasion in vein by VX2 carcinoma of the buccal mucosa was significant at 10 days, and a thrombogenic increase was significant during the development of a papillate increase. 4. The increase in arteria was not significant, but was significant in destructive changes of the endothelial cells by VX2 carcinoma. 5. The invasion in nerve bundles and nerve fibers was not significant, but a slight degeneration in nerve fibers has been found. 6. The rate of lymph node metastasis on the transplantation side was 59.5% (22/37 lymph nodes). Possibly, the rate increased with growth of the VX2 carcinoma and became higher after 15 days. 7. The metastasis on the transplantation side of lymph node was accompanied by an invasion of lymph vessels and vein in VX2 carcinoma of the buccal mucosa. There are also a further significant on the factors for prognostic judgement.
九州歯科学会の論文
1997-02-25

ウサギ頬粘膜癌(VX2 癌)における脈管神経への影響に関する実験的研究

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