Scaffold proteins in mammalian MAP kinase cascades

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概要

• 論文の詳細を見る

• The mitogen-activated protein kinase (MAPK) signaling pathway, which is conserved from yeast to humans, is activated in response to a variety of extra- and intracellular stimuli, and plays key roles in multiple cellular processes, including proliferation, differentiation, and apoptosis. The MAPK pathway transmits its signal through the sequential phosphorylation of MAPK kinase kinase to MAPK kinase to MAPK. Specific and efficient activation of the MAPK cascades is crucial for proper cellular responses to stimuli. As shown in yeast, the mammalian MAPK signaling system may also employ scaffold proteins, in part, to organize the MAPK signaling components into functional MAPK modules, thereby enabling the efficient activation of specific MAPK pathways. This review article describes recent advances in the study of potential mammalian scaffold proteins that may help us understand the complex regulation, including the spatial and temporal control, of the mammalian MAPK signaling pathways.

• 日本生化学会 = Japanese Biochemical Societyの論文
• 2004-06-01

著者

• Yoshioka Katsuji

  Div. Of Molecular Cell Signaling Cancer Res. Inst. Kanazawa Univ. 13-1 Takaramachi Kanazawa 920-0934

• Yoshioka Katsuji

  金沢大学がん研究所 シグナル伝達研究分野

• Yoshioka Katsuji

  Division Of Molecular Cell Signaling Department Of Molecular And Cellular Biology Cancer Research In

• Yoshioka Katsuji

  Division Of Cell Cycle Regulation Department Of Molecular And Cellular Biology Cancer Research Insti

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