Serial Changes of Intrathecal Viral Loads Evaluated by Chemiluminescence Assay and Nested PCR with Aciclovir Treatment in Herpes Simplex Virus Encephalitis
スポンサーリンク
概要
- 論文の詳細を見る
Objective We assessed the potential for estimating the effects of antiviral therapy on the clearance of intrathecal herpes simplex virus (HSV) antigens as evaluated by the chemiluminescence assay (CL) and on that of intrathecal HSV-DNA as evaluated by the nested polymerase chain reaction (PCR) in serial patients with herpes simplex virus encephalitis (HSVE). Methods The materials comprised serial cerebrospinal fluid (CSF) samples from 18 patients with HSVE. All patients were diagnosed as having HSVE retrospectively based on the detection of intrathecal HSV antigens by the CL, that of HSV-DNA by the nested PCR, and also serological confirmation of intrathecal antibody production. The relationships between the days of aciclovir therapy and serial HSV viral loads as evaluated by the CL and nested PCR in the serial CSFs were assessed. Results The serial intrathecal viral loads evaluated by the CL and nested PCR declined after the commencement of aciclovir administration in all patients. The serial alterations of the intrathecal viral load evaluated by the CL in each patient were similar to those of the intrathecal viral load evaluated by the nested PCR. The initial and maximum viral loads evaluated by the CL and nested PCR showed a wide distribution in the CSF samples taken from the patients with poor and good outcomes. Differences in the means of the viral loads in the CSF samples taken from the patients between a poor outcome and a good outcome were not evident. A transient increase of viral load as evaluated by these two methods was noted in the same 4 patients. The viral loads in these 4 patients also declined in the subsequent CSF samples. The outcome of these 4 patients was good in one patient and poor in the others. Conclusion Evaluation of intrathecal viral antigens by the CL has a potential for estimating the effects of antiviral therapy, as does evaluation of the intrathecal HSV-DNA by the nested PCR. The intrathecal viral loads evaluated by CL and nested PCR were not a predictor of outcome in HSVE.
- 社団法人 日本内科学会の論文
- 2004-09-01
著者
-
MORISHIMA TSUNEO
Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutic
-
MIZUTANI Tomohiko
Division of Neurology, Department of Medicine, Nihon University School of Medicine
-
Takasu Toshiaki
Division Of Neurology Department Of Medicine Nihon University School Of Medicine
-
Mizutani Tomohiko
Division Of Neurology Department Of Medicine Nihon University School Of Medicine
-
KAMEI Satoshi
Division of Neurology, Department of Medicine, Nihon University School of Medicine
-
Morishima Tsuneo
Department Of Health Science Nagoya University
-
Kamei Satoshi
Division Of Neurology Department Of Medicine Nihon University School Of Medicine
関連論文
- DHPLCを用いた日本人骨形成不全症(OI)におけるI型コラーゲンの遺伝子解析
- ビスホスホネートで治療された骨形成不全症乳幼児の成長に関する検討
- Impaired pyridinoline cross-link formation in patients with osteogenesis imperfecta
- Ubiquitin-Positive Pneumocytes and Inclusion Bodies are Present in Secondary Organizing Pneumonia
- Altered Brain Penetration of Diclofenac and Mefenamic Acid, but Not Acetaminophen, in Shiga-Like Toxin II-Treated Mice
- Ubiquitin-Positive Foam Cells are Identified in the Aortic and Mitral Valves with Atherosclerotic Involvement
- Possibility of Preventive Treatment for EBV-associated NK Cell-lineage Proliferative Disorders
- 左心低形成症候群の三尖弁逆流に対する術前管理の重要性
- Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model
- Unique maternal deletion of 15q in a patient with some symptoms of Prader-Willi syndrome
- Guidelines for care of pregnant women carrying hepatitis C virus and their infants
- Studden unexpected cardiopulmonary arrest associated with influenza infection
- Callosal lesions and delirious behavior during febrile illness
- Serum levels of cytokines and EEG findings in children with influenza associated with mild neurological complications
- Hospital-Based Study of the Prognostic Factors in Adult Patients with Acute Community-Acquired Bacterial Meningitis in Tokyo, Japan
- Predictors of a Prolonged Clinical Course in Adult Patients with Herpes Simplex Virus Encephalitis
- Tumor Necrosis Factor Receptor-associated Periodic Syndrome Mimicking Systemic Juvenile Idiopathic Arthritis
- Creutzfeldt-Jalob disease with florid plaques after cadaveric dura mater graft
- Hemiconvulsion-hemiplegia syndrome and primary human herpesvirus 7 infection
- Antipyretics and delirious behavior during febrile illness
- Delirious behavior in children with influenza : its clinical features and EEG findings
- Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7
- Comparison of Real-Time and Nested PCR Assays for Detection of Herpes Simplex Virus DNA
- Investigation of Varicella-Zoster Virus DNA in Lymphocyte Subpopulations by Quantitative PCR Assay
- Prevalence of Maternal Cytomegalovirus (CMV) Antibody and Detection of CMV DNA in Amniotic Fluid
- A female infant successfully treated by ganciclovir for congenital cytomegalovirus infection
- Detection of Herpesvirus DNA in the Serum of Immunocompetent Children
- Immunohistochemical Studies on the Transneuronal Spread of Virulent Herpes Simplex Virus Type 2 and Its US3 Protein Kinase-Deficient Mutant after Ocular Inoculation
- Longitudinal analysis of Epstein-Barr virus-associated illness
- Apoptosis under hypercytokinemia is a possible pathogenesis in influenza-associated encephalopathy
- 日本における先天性サイトメガロウイルス感染症全国調査
- Relationships between Quantitative Electroencephalographic Alterations and the Severity of Hepatitis C Based on Liver Biopsy in Interferon-α Treated Patients
- Association of Cytomegalovirus with Infantile Hepatitis
- Pramipexole Reduces the Prevalence of Fatigue in Patients with Parkinsons Disease
- Differences in clinical manifestations of influenza-associated encephalopathy by age
- Isolated Oculomotor Nerve Palsy in Churg-Strauss Syndrome
- Increase of tumor necrosis factor-α in the blood induces early activation of matrix metalloproteinase-9 in the brain
- Serial Changes of Intrathecal Viral Loads Evaluated by Chemiluminescence Assay and Nested PCR with Aciclovir Treatment in Herpes Simplex Virus Encephalitis
- 健康小児における尿中I型コラーゲン架橋N末端テロペプチド
- Isolation of a Kawasaki disease-associated bacterial sequence from peripheral blood leukocytes
- Pathological study of pseudohypertrophy of the inferior olivary nucleus
- Case of probable Creutzfeldt-Jakob disease presenting with complex partial seizure following sleeplessness and cognitive impairment
- Abducens Nerve Palsy and Horner Syndrome Due to Metastatic Tumor in the Cavernous Sinus
- ADOPTIVE IMMUNE THERAPY FOR EB VIRUS-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS
- Mitochondrial Encephalomyopathy Associated with Diabetes Mellitus, Cataract, and Corpus Callosum Atrophy
- Miller Fisher Syndrome Associated with Influenza A Infection
- Clinical Study of the Responsible Lesion for Dysarthria in the Cerebellum
- Tumor necrosis factor-α can induce Langhans-type multinucleated giant cell formation derived from myeloid dendritic cells
- Regional Variation in Survival Following Pediatric Out-of-Hospital Cardiac Arrest
- Nationwide Survey of Acute Juvenile Female Non-Herpetic Encephalitis in Japan: Relationship to Anti-N-Methyl-D-Aspartate Receptor Encephalitis
- Opsoclonus-Myoclonus Syndrome Following Influenza A Infection
- Late-onset Lymphedema and Protein-losing Enteropathy with Noonan Synerome