トリフルオロメチルケトン類の新規合成法の開発と創薬
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概要
- 論文の詳細を見る
Trifluoromethyl ketones (TFMKs) are of considerable current interest due to their importance as synthetic intermediates and their ability to act as potent enzyme inhibitors. This article briefly reviews recent ten-years progress in the chemistry of TFMKs and describes our studies on the new method for the preparation of TFMKs. Furthermore, screenings of a variety of structurally diverse TFMKs, with the view to identify a lead TFMK with anti-<I>Helicobacter pylori</I>, antimicrobial or apoptosis-inducing and -inhibitory activities are shown. These studies led to the identification of several TFMKs as a lead molecule.
- 社団法人 有機合成化学協会の論文
- 2001-08-01
著者
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