葛根湯製剤の作用機序の薬理学的検討 : イヌによる体温上昇と免疫能活性について

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In this study, using dogs as experimental models, we observed body temperature rise following administration of "Kakkon-to" preparation, and investigated the average number of macrophages and average rate of phagocytosis of macrophages in blood using the latex microparticles. The body temperature of the Kakkon-to-treated dogs significantly increased 30 minutes after administration (p<0.05). After that, the body temperature was still high until the next administration at 8 hours. When the difference in body temperature before and after administration was compared with that of the control group, a significant in crease was maintained from 1 to 12 hours after administration. The phagocytotic activity of macrophages was also increased. The average number and the average rate of phagocytosis were significantly increased 1 (p<0.05) and 2 (p<0.01) hours after administration, respectively, in comparison with the activity before administration. The significant increases (p<0.01) in both the number and the rate of phagocytosis were continuously found at every measurement point from 2 to 24 hours after administration. In addition, when compared with the control group, the test group showed a significant administration in both the number and the rate of phagocytosis at 3 hours after administration (p<0.01). These results demonstrated that administration of "Kakkon-to" not only increased the body temperature but also enhanced the phagocytic activity of macrophages, the in vivo defensive factors, suggesting that "Kakkon-to" may contribute to the suppression of multiplication of common cold viruses and influenza viruses, which consequently results in improvement of various symptoms during infection with common cold syndrome.
和漢医薬学会の論文
2003-02-20

葛根湯製剤の作用機序の薬理学的検討 : イヌによる体温上昇と免疫能活性について

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