Repeated immobilization stress increases uncoupling protein 1 expression and activity in Wistar rats

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概要

• 論文の詳細を見る

• The Physiological Society of Japan , Gao, Bihu ; Kikuchi-Utsumi, Kazue ; Ohinata, Hiroshi ; Hashimoto, Masaaki ; Kuroshima, Akihiro, Japanese Journal of Physiology, 53(3), 2003, 205-213.publisherRepeat immobilization-stressed rats are leaner and have improved cold tolerance due to enhancement of brown adipose tissue (BAT) thermogenesis. This process likely involves stress-induced sympathetic nervous system activation and adrenocortical hormone release, which dynamically enhances and suppresses uncoupling protein 1 (UCP1) function, respectively. To investigate whether repeated immobilization influences UCP1 thermogenic properties, we assessed UCP1 mRNA, protein expression, and activity (GDP binding) in BAT from immobilization-naïve or repeatedly immobilized rats (3 h daily for 4 weeks) and sham operated or adrenalectomized (ADX) rats. UCP1 properties were assessed before (basal) and after exposure to 3 h of acute immobilization. Basal levels of GDP binding and UCP1 expression was significantly increased (140 and 140%) in the repeated immobilized group. Acute immobilization increased GDP binding in both naïve (180%) and repeated immobilized groups (220%) without changing UCP1 expression. In ADX rats, basal GDP binding and UCP1 gene expression significantly increased (140 and 110%), and acute immobilization induced further increase. These data demonstrate that repeated immobilization resulted in enhanced UCP1 function, suggesting that enhanced BAT thermogenesis contributes to lower body weight gain through excess energy loss and an improved ability to maintain body temperature during cold exposure.

• Physiological Society of Japanの論文
• 2003-06-01

著者

• Kikuchi(utsumi) Kazue

  Department Of Physiology 1 Asahikawa Medical University School Of Medicine

• Ohinata Hiroshi

  Department Of Physiology 1 Asahikawa Medical University School Of Medicine

• Kuroshima Akihiro

  Department Of Physiology 1 Asahikawa Medical University School Of Medicine

• GAO Bihu

  Department of Physiology 1, Asahikawa Medical University School of Medicine

• HASHIMOTO Masaski

  Department of Physiology 1, Asahikawa Medical University School of Medicine

• Gao B

  Department Of Physiology 1 Asahikawa Medical University School Of Medicine

• Hashimoto Masaski

  Department Of Physiology 1 Asahikawa Medical University School Of Medicine

• Kikuchi-Utsumi Kazue

  Department of Physiology 1, Asahikawa Medical University School of Medicine

• Ohinata H

  Department of Physiology 1, Asahikawa Medical University School of Medicine

• Kuroshima A

  Department of Physiology 1, Asahikawa Medical University School of Medicine

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• Effects of Fasting and Refeeding on Some Metabolic Characteristics of Rat Brown Adipose Tissue
• Physiological Role of Brown Adipose Tissue in Cold Acclimation : With Special Reference to the Participation of Endocrine Factors
• Repeated immobilization stress increases uncoupling protein 1 expression and activity in Wistar rats

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