Nitroprusside Inhibits Kindling Development and Potentiates Excitatory Amino Acid Exocytosis in the Kindling Rat

概要

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The effect of sodium nitroprusside (SNP), one of the nitric oxide (NO) donors, on the development of acute amygdaloid kindling and amino acid exocytosis in the hippocampus of kindled rats was examined using in vivo microdialysis. The number of stimulations required for rats perfused with 10 mM SNP through the ventral hippocampus prior to the first kindling stimulation was larger than that of control, and the afterdischarge duration was shorter than that of control. On the other hand, SNP-induced enhancement of aspartate, glutamate and glycine overflow in the established kindled rats was greater than that in control. This SNP-induced enhancement of amino acid overflow was TIX-insensitive. These results suggest that NO has at least two roles in kindling; to accelerate amino acid exocytosis, and to inhibit kindling development.
日本脳科学会の論文
1997-03-01