Novel Molecular Therapeutic Approach to Cardiovascular Disease Based on Hepatocyte Growth Factor
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概要
- 論文の詳細を見る
- 2000-06-01
著者
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Morishita Ryuichi
Division Of Gene Therapy Science Osaka University Graduate School Of Medicine
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Ogihara Toshio
Department Of Geriatic Medicine
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Tomita Naruya
Division Of Nephrology Department Of Internal Medicine Kawasaki Medical School
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Tomita Naruya
Department Of General Medicine Osaka University Graduate School Of Medicine
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Tomita Naruya
Osaka University Graduate School Of Medicine
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Morishita Ryuichi
Department Of Clinical Gene Therapy
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Higaki Jitsuo
Department Of Ehime University Graduate School Of Medicine
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Morishita Ryuichi
Department Cf Clinical Gene Therapy Graduate School Of Medicine Osaka University
関連論文
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- Genetic basis of hypertension for the development of tailored medicine
- OE-071 A Genom-Wide Association Study of SNPs in the risk of Atherosclerosis Obliterans(Heart failure, clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- DPJ-013 Hepatocyte Growth Factor Attenuates TGF-β1 Angiotensin II Crosstalk by Down Regulation of Angiotensin II Type 1 Receptor through PTEN/Akt Pathway(DPJ03,Kidney/Renal Circulation/CKD (H),Digital Poster Session (Japanese),The 73rd Annual Scientific M
- Variation in OSBPL10 is associated with dyslipidemia
- Serum hepatocyte growth factor concentration is a specific marker of endothelial dysfunction in humans
- Association of Serum Oxidized Lipoprotein(a) Concentration with Coronary Artery Disease : Potential Role of Oxidized Lipoprotein(a) in the Vasucular Wall
- PJ-042 Pivotal Roles of CYLD (cylindromatosis) as a Deubiquitinating Enzyme in Vasculature(Atherosclerosis, basic(05)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Recognition of Tissue- and Subtype-Specific Modulation of Angiotension II Receptors Using Antibodies against AT_1 and AT_2 Receptors
- Symposium on The Etiology of Hypertension - Summerizing Studies in 20th Century -, Hypertension and Genes
- Lack of Association between the Hepatocyte Growth Factor Receptor, c-met, and the Anti-Apoptotic Action of Bag-1 in Endothelial Cells
- Recovery of Learning and Memory by Gene Therapy Using Hepatocyte Growth Factor Gene After Focal Cerebral Ishcemia in Rats(Gene Therapy/Genetic Engineering (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Gene Polymorphism of Myospryn (Cardiomyopathy-Associated 5) Is Associated with Left Ventricular Wall Thickness in Patients with Hypertension
- Inhibitory Effect of Chimera Decoy Oligodeoxynucleotides (ODN) against Ets and NFκ B on the Progression of Rabbit Experimental Aortic Aneurysms (AAA)
- Gene Therapy for Abdominal Aortic Aneurysm (AAA) using Decoy Strategy against ets binding site
- Effect of E2F decoy on inhibitation of neointima formation in pig coronary arteries after balloon injury and stent implantation
- Transcription factor, ets-1, is a novel angiogenic molecule : Implication to ciene therapy to treat peripheral arterial disease
- Novel molecular intervention to treat abdominal aortic aneurysms (AAA) using chimera decoy oligodeoxynucleotides (ODN) against ets and NFkB binding sites
- Therapeutic Angiogenesis Induced by Endotherial Nitric Oxide Synthase Gene through VEGF Expression in Rat Hindlimb Ischemia Model
- Polymorphism of myospryn is associated with left ventricular diastolic dysfunction
- Increase in DNA Synthesis of Cardiac Myocytes by Transfection ofP53 and Rb Antisense : Possibility of Cardiac Myocytes Regeneration
- PJ-145 Periostin as a Novel Therapeutic Target for Heart Failure(Acute coronary syndrome, basic/clinical-7, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-024 New Mechanisms of an Angiotensin Receptor Blocker, Valsartan, on the Heart Failure through the Inhibition of Novel Anti-adhesion Molecule, Periostin(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific
- Periostin as a Anti-adhesion Molecule Responsible for Ventricular Dilation(Heart Failure, Basic 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-003 Docking Protein Gab1 is Essential for HGF-dependent Endothelial Signaling and Angiogenesis after Hindlimb Ischemia(FRS1,New Molecules for Cardiovascular Regulation (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The J
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- Nonviral HVJ (hemagglutinating virus of Japan) liposome-mediated retrograde gene transfer of human hepatocyte growth factor into rat nervous system promotes functional and histological recovery of the crushed nerve
- PE-062 Zyxin Progresses Epithelial-Mesenchymal Transition under the Control of Twist1 and Contributes to Endocardial Morphogenesis(PE011,Congenital Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation S
- IS023 Antisense Proliferating-cell Nuclear Antigen Oligonucleotide Attenuates Cardiac Allograft Arteriopathy
- PJ-086 Regression of Experimental Rabbit Aortic Aneurysm by The Treatment with Chimera Decoy Oligodeoxynucleotides (ODN) against ets and NFkB(Gene Therapy 1 (IHD) : PJ15)(Poster Session (Japanese))
- OJ-094 Delayed Post-ischemic Treatment with Fluvastatin Improved Learning and Memory Deficit After Stroke in Rats without affecting Infarction Volume(Cerebrovascular circulation / Stroke-1, The 71st Annual Scientific Meeting of the Japanese Circulation So
- PJ-654 Post-ischemic Administration of Fluvastatin Improves Cognitive Dysfunction in the Chronic Stage of Cerebral Infarction in Rat Model(Cerebrovascular circulation/Stroke-3 (H) PJ110,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meet
- PJ-652 Over-expression of HGF Improves Learning and Memory and Prevents Progressive Shrinkage of Thalamus in the Chronic Stage of Cerebral Infarction(Cerebrovascular circulation/Stroke-3 (H) PJ110,Poster Session (Japanese),The 70th Anniversary Annual Scie
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- PJ-740 Hepatocyte Growth Factor (HGF), but not Vascular Endothelial Growth Factor (VEGF), Attenuated Ang II-induced EC Senescence by Inhibiting PIP3/rac1 Activity(PJ124,Peripheral Cirulation/Vascular Disease (Therapy) 4 (H),Poster Session (Japanese),The 7
- OJ-060 Hepatocyte Growth Factor Attenuate Ang II-induced Inflammation and Proliferation of Smooth Muscle Cell through EGF Receptor Degradation(OJ10,Atherosclerosis, Basic (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanes
- PJ-686 Hepatocyte Growth Factor Can Attenuate Senescense of EPC through Anti-oxidative Stress Effect(Peripheral circulation/Vascular disease-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Application of Decoy Oligodeoxynucleotides for Arthritis
- 3 Functional Analysis of Novel Antimicrobial Peptide, AG (Angiogenic Peptide)-30, with Angiongenic Property, toward Clinical Application(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Hepatocyte Growth Factor(HGF) as a Potential Index of Severity of Hypertension
- IS033 UP-REGULATION OF KEY TRANSCRIPTIONAL FACTOR FOR ANGIOGENESIS, ETS, AND INDUCTION OF ANGIOGENESIS BY IN VIVO GENE TRANSFER OF HUMAN HEPATOCYTE GROWTH FACTOR (HGF) INTO MYOCARDIUM
- IS028 GENE THERAPY OF RESTENOSIS BY IN VIVO GENE TRANSFER OF HUMAN HEPATOCYTE GROWTH FACTOR (HGF) THROUGH THE ACCELATION OF RE-ENDOTHELIALIZATION
- Contribution of a Vascular Modulator, Hepatocyte Growth factor (HGF), to the Pathogenesis of Cardiovascular Disease
- IS053 ANTI-APOPTOTIC ACTION OF HEPATOCYTE GROWTH FACTOR ON HUMAN AORTIC ENDOTHELIAL CELLS
- Potential Role of a Novel Vascular Modulator, Hepatocyte Growth Factor (HGF), in Cardiovascular Disease: Characterization and Regulation of Local HGF System
- PE-275 A Novel Strategy of the Gene Therapy for PAD Using Small RNA Interference of Cold Shock Domain Protein A(PE046,Atherosclerosis (Basic, Clinical/Diagnosis) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation
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- PJ-250 Cold shock domain protein A, novel regulator of angiogenesis in heart.(Coronary circulation, basic/clinical(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-185 Topical application of novel angiogenic peptide, AG-30, in wound healing model(Growth factor/Cytokine(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
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- PJ-477 A Therapeutic Strategy to Treat Brain Ischemia : Over-expression of Hepatocyte Growth Factor Gene Reduced Ischemic Injury in Rat Model(Cerebrovascular Circulation/Stroke 1 (H) : PJ80)(Poster Session (Japanese))
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- OJ-125 HGF,but not VEGF, Attenuated Angiotensin II-induced Senescence in EPC through Anti-Oxidative Stress Effect by Inhibiting Rac1 Activation.(Regeneration(angiogenesis / myocardial regeneration)(02)(M),Oral Presentation (Japanese),The 72nd Annual Scien
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- PJ-188 Angiogenic and Anti-fibrotic Actions of Hepatocyte Growth Factor Improve Cardiac Dysfunction in Porcine Ischemic Cardiomyopathy(Genetics/Genetically engineered models/Gene therapy-3 (M) PJ32,Poster Session (Japanese),The 70th Anniversary Annual Sci
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- PE-114 Angiotensin II Blocker, Valsartan, Supresses the Development of Experimental Abdominal Aortic Aneurysm in Rats(Peripheral circulation/Vascular disease(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
- Aging of Blood Vessels
- PJ-691 Inhibition of Development of Experimental Aortic Abdominal Aneurysm in Rat Model by Atorvastatin through Inhibition of Macrophage Migration(Peripheral circulation/Vascular disease-6, The 71st Annual Scientific Meeting of the Japanese Circulation So
- PE-543 Inhibiton of Experimental Aortic Abdominal Aneurysm by Angiotensin Receptor Blocker, Valsartan(Peripheral circulation/Vascular disease-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Two Years Follow-up of Clinical Trial of Human Gene Therapy for Peripheral Arterial Disease Using Hepatocyte Growth Factor Gene Transfer(Peripheral Circulation/Vascular Disease (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Clinical Trial of Human Gene Therapy Using Hepatocyte Growth Factor Gene Transfer(Translational Research in Cardiovascular Disease, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-013 Long Term Evaluation of Clinical Trial of Human Gene Therapy for Peripheral Arterial Disease Using Hepatocyte Growth Factor Gene Transfer(Angiogenesis and Regeneration Medicine in Cardiovascular Medicine (M) : FRS3)(Featured Research Session (Engl
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- Inhibition of Restenosis by Beraprost Sodium (a Prostaglandin 12 Analogue) in the Porcine Coronary Artery after Angioplasty
- Results of Safety from Human Clinical Gene Therapy Using HGF (TREAT-HGF)
- Long Term Evaluation of Results from the First Stage in the Clinical Trial of Gene Therapy for Peripheral Arterial Disease
- Clinical Results of TREAT-HGF (Japan Trial to Treat Peripheral Arterial Disease by Therapeutic Angiogenesis Using Hepatocyte Growth Factor Gene Transfer)
- Evaluation of utility of prostagrandin E1 in the patients with ASO : Protective effect on endothelial function through up-regulation of HGF
- No increase in human HGF concentration in the patients transfected with human HGF plasmid : preliminary clinical results from TREAT-HGF
- Preliminary clinical results from TREAT-HGF (Japan Trial to Treat Peripheral Arterial Disease by Therapeutic Angiogenesis Using HGF Gene Transfer)
- Preliminary clinical results from TREAT-HGF : Gene therapy for PAD
- OJ-213 Prevention of Abdominal Aortic Aneurysm using Ribbon-type Chimeric Decoy Oligodeoxynucleotides against NF κ B and Ets in a Rat Model(Genetics/Genetically engineered models/Gene therapy-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circ
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- 5 Clinical Trial of Human Gene Therapy for Peripheral Arterial Disease Using Hepatocyte Growth Factor Gene Transfer(Clinical Trials of Regeneration Therapy in Japan, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-391 Hypertension Accelerated Experimental Abdominal Aortic Aneurysm through Up-regulation of Transcription Factors, NFkB and Ets(Peripheral circulation-2 (H) OJ66,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
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- Regression of Experimental Rabbit Aortic Aneurysm by the Treatment with Chimeric Decoy Oligodeoxynucleotides (ODN) against Ets and NFkB(Gene Therapy 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Inhibitory Effect of NFκB Decoy Oligodeoxynucleotides (ODN) on the Neointimal Hyperplasia in Rabbit Vein Graft Model(Cardiovascular Surgery/CABG 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-090 Therapeutic angiogenesis by a transcription factor : Ets-1 for peripheral arterial disease(Gene Therapy 1 (IHD) : PJ15)(Poster Session (Japanese))
- OE-328 Increase in DNA Synthesis of Cardiomyocytes by Transfection of Antisense p53 and Rb Oligodeoxynucleotides : Possibility of Regeneration of Cardiomyocytes(Gene Therapy 2 (IHD) : OE41)(Oral Presentation (English))
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- Therapeutic Angiogenesis Induced by Transfection of Hepatocyte Growth Factor (HGF) Gene in Porcine Myocardial Infarction Model
- Acceleration of Neointimal Hyperplasia in Lp (a) Transgenic Mice : Contribution of Lp (a) in the Pathogenesis of Vascular Disease
- Hepatocyte Growth Factor as Cardiovascular Hormone: Role of HGF in the Pathogenesis of Cardiovascular Disease
- Novel High Efficiency Gene transfer Technique into neonatal cardiac myocyte : Second Generation of HVJ vector (HVJ-envelope)
- Gene therapy for preventing delayed neuronal death using hepatocyte growth factor
- Impairment of collateral formation in Lp(a) transgenic mice : Therapeutic angiogenesis induced by human hepatocyte growth factor (HGF) gene
- Acceleration of neointimal hyperplasia in Lp(a) transgenic mice : Contribution of Lp(a) in the pathogenesis of vascular disease
- Novel Molecular Therapeutic Approach to Cardiovascular Disease Based on Hepatocyte Growth Factor (HGF)
- PJ-341 Acceleration of wound healing by combination gene transfer of Hepatocyte Growth Factor and Prostacyclin Synthase with Shima Jet(Peripheral Circulation/Vascular Disease 3(H) : PJ57)(Poster Session (Japanese))
- PJ-751 Role of HIF-1 α on Vascular and Heart Development in Xenopus : HIF-1 α Regulated Cardiac Development Independent of Vascular or Blood Development(Development and differentiation-4 (M) PJ129,Poster Session (Japanese),The 70th Anniversary Annual Scie