Enzyme-inhibition system for identifying potential antimalarials that target highly drug-resistant mutants of Plasmodium falciparum dihydrofolate reductase

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概要

• 論文の詳細を見る
• Elsevierの論文
• 1998-03-01

著者

• HORII Toshihiro

  Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University

• Iwakura Masahiro

  National Institute of Advanced Industrial Science and Technology

• Brobey Reynolds

  Department Of Molecular Protozoology Research Institute For Microbial Diseases Osaka University

• Horii Toshihiro

  Department Of Molecular Protozoology Instisute For Microbial Diseases Osaka University

• Iwakura Masahiro

  National Institute Of Bioscience And Human Technology

• Itoh Fumio

  Pharmaceutical Research Laboratories Iii. Takeda Chemical Industries Ltd.

• Itoh Fumio

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• ASO Kazuyoshi

  Pharmaceutical Research Division, Takeda Chemical Industries Ltd.

• Iwakura Masahiro

  National Institute For Advanced Interdisciplinary Research

• Aso Kazuyoshi

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

関連論文

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• Structural Basis for the Decarboxylation of Orotidine 5'-Monophosphate (OMP) by Plasmodium Falciparum OMP Decarboxylase
• Cloning and Characterization of Ferredoxin and Ferredoxin-NADP^+ Reductase from Human Malaria Parasite
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• Sequence diversity in the amino-terminal region of the malariavaccine candidate serine repeat antigen in natural Plasmodium falciparum populations
• Phylogenetic identification of Sparganum proliferum as a pseudophyllidean cestode
• Cyanocysteine-Mediated Molecular Dissection of Dihydrofolate Reductase: Occurrence of Intra- and Inter-Molecular Reactions Forming a Peptide Bond
• Nano-Scale Monitoring of the Thermally-Induced Unfolding of Proteins Using Capillary Electrophoresis with In-Column Incubation
• Acceleration of The Dissection Reaction at Cyanocysteine Residue by Neighboring Lysine
• DNA immunization with Plasmodium falciparum serine repeat antigen: regulation of humoral immune response by coinculation of cytokine expression plasmid
• Non-glutamate Type Pyrrolo[2,3-d]pyrimidine Antifolates. II. Synthesis and Antitumor Activity of N^5-Substituted Glutamine Analogs
• Plasmodium falciparum serine-repeat antigen (SERA) forms a homodimer through disulfide bond
• Differential localization of processed fragments of Plasmodium falciparum serine repeat antigen and further processing of its N-terminal 47 kDa fragment
• Enzyme-inhibition system for identifying potential antimalarials that target highly drug-resistant mutants of Plasmodium falciparum dihydrofolate reductase
• Pathological role of Toll-like receptor signaling in cerebral malaria
• Effects of Mutation at Methionine-42 of Escherichia coli Dihydrofolate Reductase on Stability and Function : Implication of Hydrophobic Interactions
• Protective immunity induced in squirrel monkeys with recombinant serine repeat antigen (SERA) of Plasmodium falciparum
• Relative frequencies of polymorphisms of variation in Block 2 repeats and 5' recombinant types of Plasmodium falciparum msp 1 alleles
• Introduction of Cysteine Residue to Engineered Cys-Free Dihydrofolate Reductase and Its Application for the Specific Molecular Dissection
• Availability of Dihydrofolate Reductase Affinity Handle in Expressing Human Prolactin as a Soluble Fusion Protein
• In Search of Circular Permuted Variants of Escherichia coli Dihydrofolate Reductase
• Synthesis and Structure-Activity Relationships of TAN-1511 Analogues as Potent Hematopoietic Agents
• Evasion of Host Immune System by Malaria Parasite, Plasmodium falciparum, at an Asexual Stage(Abstracts from the Malaria Workshop)
• Serum factors governing intraerythrocytic development and cell cycle progression of Plasmodium falciparum
• Development of malaria vaccine based on recombinant SERA protein
• Molecular Interaction of Ferredoxin and Ferredoxin-NADP^+ Reductase from Human Malaria Parasite
• Stability and Reversibility of Thermal Denaturation Are Greatly Improved by Limiting Terminal Flexibility of Escherichia coli Dihydrofolate Reductase
• Topological Mutation of Escherichia coli Dihydrofolate Reductase
• The Malarial Metabolite Hemozoin and Its Potential Use as a Vaccine Adjuvant
• Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE36
• Stability and Reversibility of Thermal Denaturation Are Greatly Improved by Limiting Terminal Flexibility of Escherichia coli Dihydrofolate Reductase.

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