Effects of Toluene on Regulation of Adenylyl Cyclase by Stimulation of G-Protein-Coupled Receptors Expressed in CHO Cells
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概要
- 論文の詳細を見る
We determined the effects of toluene exposure on activation or inhibition of adenylyl cyclase by stimulating human β2-adrenergic receptors (β2-AR) and muscarinic acetylcholine receptor (mAChR) m2 subtypes, respectively, expressed in CHO cells. The formation of cAMP via β2-AR stimulation was slightly but not significantly facilitated in the presence of 3.7 μM toluene. On the other hand, the inhibition of adenylyl cyclase by 10 μM of carbamylcholine stimulation of mAChR m2 subtypes was attenuated in the presence of toluene. These results strongly suggest that toluene affects activation of Gi rather than Gs.
- 社団法人 日本薬理学会の論文
著者
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Honma Takeshi
Division Of Health Effects Research National Institute Of Industrial Health
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Wang Rui-sheng
Division Of Health Effects Research National Institute Of Industrial Health
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Tsuga Hirofumi
Division Of Health Effects Research National Institute Of Industrial Health
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TSUGA Hirofumi
Division of Health Effects Research, National Institute of Industrial Health
関連論文
- Effects of Toluene on Regulation of Adenylyl Cyclase by Stimulation of G-Protein-Coupled Receptors Expressed in CHO Cells
- P-53 Changes in brain muscarinic receptors induced by toluene(Proceedings of the 27th Annual Meeting)
- 22B-10-2 Effects of Toluene Exposure on Brain Cholinergic Neurons.
- Assessment of the Genotoxicity of 1,2-Dichloropropane and Dichloromethane after Individual and Co-exposure by Inhalation in Mice