Effect of Recombinant Human Insulin-Like Growth Factor-I on Expression of Glucose Transporters, GLUT 2 and GLUT 4, in Streptozotocin-Diabetic Rat

スポンサーリンク

概要

• 論文の詳細を見る

• We investigated the effect of recombinant insulin-like growth factor-I (rhIGF-I) on the expression of glucose transporters, GLUT 2 in the liver and GLUT 4 in the heart, in streptozotocin (STZ)-diabetic rats by the reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. GLUT 2 and its mRNA in the liver was elevated, whereas GLUT 4 and its mRNA in the heart were decreased in STZ-diabetic rats. A two-week treatment with rhIGF-I mostly restored the expression of GLUT 2 and GLUT 4 to normal rat level. We demonstrated that the effect of IGF-I on the expressions of GLUTs was almost the same as that of insulin.

• 社団法人 日本薬理学会の論文

著者

• KOBAYASHI Masakazu

  Fujisawa Pharmaceutical Co., Ltd.,

• IWAI Michio

  Department of Chemistry. Faculty of Liberal Arts and Scinece, Marine Technical College

• Iwai Michio

  Department Of Chemistry Marine Technical College

• ASADA Takashi

  Molecular Biological Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• OGAWA Toshikazu

  Pharmacological Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Asada Takashi

  Molecular Biological Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Ogawa Toshikazu

  Pharmacological Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Kobayashi Masakazu

  Fujisawa Research Institute Of America Inc. Northwestern University

関連論文

• Direct Identification of a Novel Disulfide Bond Linkage System of New Isolated Isomer (Isomer V) in Recombinantly Produced h-IGF-I
• Synthesis of Two Possible Disulfide Bonds Containing Peptide Fragments(Cys^6-Cys^, Cys^-Cys^(Type I), and Cys^6-Cys^, Cys^-Cys^(Type II) of h-IGF-I) for the Identification of Disulfide Bond Linkage in Recombinantly Produced h-IGF-I
• Effect of Recombinant Human Insulin-Like Growth Factor-I on Expression of Glucose Transporters, GLUT 2 and GLUT 4, in Streptozotocin-Diabetic Rat
• Studies on Hydroxy Amino Acids. IV. Syntheses of Several Peptides Containing Aziridinecarboxylic Acid Derived from the Corresponding Hydroxy Amino Acid Derivatives

スポンサーリンク