Cardiac Angiotensin II Receptors Are Downregulated by Chronic Angiotensin II Infusion in Rats
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概要
- 論文の詳細を見る
We studied the effect of chronic(7 days)angiotensin II infusion in a subpressor(200ng/kg per minute)dose on angiotensin II receptors in the left ventricle in rats.Infusion of angiotensin II caused an elevation in systolic blood pressure after 3 days, usually to values of about 150 mmHg, and the increase continued during the drug administration.The number of angiotensin II type 1 and angiotensin II type 2 receptors was significantly decreased by 20−30% in the angiotensin II−infused left ventricular membranes without affecting the affinity.Thus, these data suggest that angiotensin II may regulate the number of its own receptors in rat left ventricles.
- 社団法人 日本薬理学会の論文
- 2000-09-01
著者
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TAKESHITA Akira
the Department of Cardiovascular Medicine ,Kyushu University Graduate School of Medical Science
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EGASHIRA Kensuke
the Department of Cardiovascular Medicine, Department of Medicine and Bioregulatory Science
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KATOH Makoto
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
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Katoh Makoto
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd
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Egashira Kensuke
The Department Of Cardiovascular Medicine Kyushu University Faculty Of Medicine
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Egashira Kensuke
The Department Of Cardiovascular Medicine Department Of Medicine And Bioregulatory Science
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Takeshita Akira
The Department Of Cardiovascular Medicine Kyushu University Faculty Of Medicine
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