INFLUENCE OF AROTINOLOL HYDROCHLORIDE ON HEART RATE SPECTRUM IN HYPERTENSIVE SUBJECTS
スポンサーリンク
概要
- 論文の詳細を見る
Influence of arotinolol hydrochloride and atenolol on the balance between the sympathetic and parasympathetic nervous systems was evaluated in 8 hypertensive subjects by spectral analysis of heart rate (HR) and systemic blood pressure (BP). Before and after administration of either arotinolol (n=7) or atenolol (n=7) for 2 weeks, BP was continuously and non-invasively monitored by a finger-cuff manometry (Finapres) . A time series of instantaneous HR was constructed from the BP signal. A time series of mean BP was also constructed. Spectral analysis was performed by the use of an autoregressive algorithm on these time series (〜180 sec). Each spectrum was subdivided into low-(0.05-0.15 Hz, LF) and high-frequency (0.15-0.4 Hz, HF) components, and each component was divided by the sum of the two for normalization. As a measure of the balance between the sympathetic and parasympathetic nervous systems, the ratio of LF to HF (LF/HF) was evaluated. Arotinolol increased fractional HF in the HR spectrum from 0.45±0.12 to 0.73±0.08 (p<0.01) and decreased fractional LF from 0.55±0.12 to 0.27±0.08 (p<0.01); consequently, it decreased LF/HF from 1.4±0.5 to 0.4±0.2 (p<0.01). Atenolol had similar effects on these parameters. Neither of these β-adrenergic blockades produced a discernible decrease in LF/HF in the BP spectrum. In conclusion, these β -adrenergic blockades decreased LF/HF in the HR spectrum in hypertensive subjects, which suggests that they improved the balance between the sympathetic and parasympathetic nervous systems.
- 社団法人日本循環器学会の論文
- 1994-04-20
著者
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TAKESHITA Akira
Kyushu University
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Ando Shin-ichi
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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IMAIZUMI Tsutomu
the Department of Internal Medicine III and the Cardiovascular Research Institute, Kurume University
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Asai Takashi
Department Of Cardiovascular Medicine Wakayama Medical University
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Akashi Takumi
Department Of Clinical Pathology Graduate School Of Medicine Tokyo Medical And Dental University
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Asai Takashi
The Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Harada Seiki
The Department Of Biomedical Informatics And The Research Institute Of Angiocardiology And Cardiovas
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TAKESHITA Akira
the Department of Cardiovascular Medicine ,Kyushu University Graduate School of Medical Science
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HARASAWA YASUHIKO
The Department of Biomedical Informatics and the Research Institute of Angiocardiology and Cardiovas
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ANDO SHIN-ICHI
The Department of Biomedical Informatics and the Research Institute of Angiocardiology and Cardiovas
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MASAKI HIROYUKI
The Department of Biomedical Informatics and the Research Institute of Angiocardiology and Cardiovas
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MOMOHARA MICHIKO
The Department of Biomedical Informatics and the Research Institute of Angiocardiology and Cardiovas
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ASHIHARA Toshiaki
Research Institute of Angiocardiology and Cardiovascular Clinic
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Imaizumi Tsutomu
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Imaizumi Tsutomu
The Department Of Internal Medicine Iii And The Cardiovascular Research Institute Kurume University
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Takeshita Akira
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University
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Imaizumi Tsutomu
Department Of Anesthesiology Kyushu University Medical School
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Takeshita Akira
From Reseach Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Unive
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Akiba Takashi
Tokyo Women's Medical Univ. Tokyo Jpn
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Ando Shinnichi
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Masaki Hiroyuki
The Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Unive
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Imaizumi Tsutomu
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Harasawa Yasuhiko
The Department Of Biomedical Informatics And The Research Institute Of Angiocardiology And Cardiovas
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Momohara Michiko
The Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Unive
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