α-TCP-コラーゲン材を用いた歯槽骨形成に関する実験的研究

概要

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This experimental study was conducted to investigate bone tissue reaction of apatite-collagen conjugated sponge in the healing process of bone. The bone formation in relation with microvascular construction was observed with a scanning electron microscope.<BR>Absorbable α-tricalcium phosphate-(α-TCP), α-TCP-collagen conjugated sponge having hydration activity with type I collagen gel in a short time under physiological condition and α-TCP processed with tannic acid were employed as experimental materials, and Japanese monkeys were employed as experimental animals. Artificial bone defects were made in bilateral lower premolar and molar region of the animals, and the experimental materials were inserted therein. The animals were sacrificed 2, 4 and 8 weeks after operation. Acryl plastic was injected via the common carotid arteries, utilizing the plastic injection method to prepare a microcast around the experimental region. The injected material was coated with gold for the employment of a scanning electron microscope.<BR>α-TCP processed with tannic acid promoted dense capillaries and markedly enhanced bone healing. The results indicated that the application of this material in bone defects can be useful for promoting alveolar bone formation.
社団法人日本補綴歯科学会の論文
2000-02-10