再生医療における人工膜の役割と新展開

概要

論文の詳細を見る
Tissue engineering is an interdisciplinary field that applies principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain and improve the function of damaged tissues and organs. Isolated cells cannot form new tissues on their own. They require a specific environment, in which a supporting materials (i.e., artificial polymeric membranes in this review) act as a template and a natural environment in vitro.<BR>The cell function depends on the matrices (i.e., the membranes) where the cells attach, e.g., whether the membranes contain the cell adhesion molecules (e.g., extracellular matrices, RGD, YIGSR, REDV and specific saccharides).<BR>The key factors required for polymeric membranes used for the tissue engineering are discussed; chemical, physical and biological properties. The application of the tissue engineering using the porous membranes is reviewed such as nerve regeneration using nerve entubulation made of porous gel (nerve guide), bioartificial liver and biohybrid skin composed of fibroblast cells from neonatal foreskin, silicon rubber membrane and nylon mesh as the scaffold. The membrane science such as polymeric synthesis for the novel membranes, membrane formation theory and membrane characterization in the tissue engineering is significantly important for the development of the tissue engineering.
日本膜学会の論文
2002-01-01