IQI/Jic Mice Have Thymic B Cells

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概要

• 論文の詳細を見る

• The thymus of IQI/Jic mice aged 3 to 15 months was studied chronologically by flow cytometry and immunohistochemistry. Thymic B cells (Thy B) expressing the surface marker B220+IgM+ were detected in both sexes, but were more prominent in females. Thy B appeared as early as 4 months of age in female mice, and the incidence of Thy B-positive mice and average Thy B ratio in thymocytes increased with age, reaching over 90% and 15%, respectively, after 9 months of age. In males, Thy B-positive animals appeared around 9 months of age and its incidence and average ratio increased gradually to 53% and 5%, respectively, at 15 months. The Thy B-rich thymus was thickened with cortical atrophy and medullary hyperplasia. Small-to medium-sized Thy B crowded and often formed follicle-like structures in the medulla. When mice of various ages were injected with mercuric chloride to induce antinucleolar antibody, many Thy B-rich animals could not develop the antibody, implying that these animals are immunologically impaired. IQI/Jic can be a novel strain to elucidate the relationship between the presence of Thy B and disorders of the immune system.

• 社団法人　日本実験動物学会の論文
• 1996-10-01

著者

• SAEGUSA Junzo

  Laboratory of Experimental Toxicology, National Institute of Industrial Health

• Saegusa Junzo

  Laboratory Of Experimental Toxicology National Institute Of Industrial Health

• Kubota Hisayo

  Laboratory Of Experimental Toxicology National Institute Of Industrial Health

• Yasuda Akinori

  Laboratory Of Experimental Toxicology National Institute Of Industrial Health

関連論文

• Subcapsular Cell Hyperplasia and Mast Cell Infiltration in the Adrenal Cortex of Mice: Comparative Study in 7 Inbred Strains
• Correlation of Mast Cells with Spindle Cell Hyperplasia in the Adrenal Cortex of IQI/Jic Mice
• IQI/Jic Mice Have Thymic B Cells

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