Testicular Spermatid and Epididymal Sperm Head Counts as an Indicator for Reproductive Toxicity in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The testes of rats were exposed to a single soft x-ray irradiation at levels of 10, 25 and 63 Gy. Testicular and cauda epididymal weights and their sperm counts were decreased at 7 weeks after the irradiation. Histologically, there was an evidence of interrupted spermatogenesis dose-dependently. Animal mating trails, in which irradiated males were mated with untreated females revealed a slight increase in early stage of postimplantation loss at as low as 10 Gy. There were increases in preimplantation and early stage of postimplantation losses in the group of irradiated at 25 Gy. Infertility occurred in irradiated males at 63 Gy. The effects of irradiation were more severe on the sperm count parameters than on reproductive organ weights, histological examination and reproductive status. The testicular spermatid and epididymal sperm head counts are considered to be useful indicators to detect quantitatively the adverse effects on spermatogenesis.
- 社団法人 日本実験動物学会の論文
- 1995-10-01
著者
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INAGAKI Satoru
Safety Assessment, Development and Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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Ban Yoshiki
Tsukuba Safety Assessment Laboratories, Banyu Pharmaceutical Co., Ltd.
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Ban Y
Tsukuba Safety Assessment Laboratories Banyu Pharmaceutical Co. Ltd.
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Inagaki S
Meiji Univ. Kawasaki
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Inagaki Satoru
Safety Assessment Development And Research Laboratories Banyu Pharmaceutical Co. Ltd.
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Inagaki Satoru
The Institute For Solid State Physics The University Of Tokyo
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KEMI Masayuki
Tsukuba Safety Assessment Laboratories, Banyu Pharmaceutical Co., Ltd.
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NAKATSUKA Toshio
Tsukuba Safety Assessment Laboratories, Banyu Pharmaceutical Co., Ltd.
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BAN Yoshiki
Development Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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KOMATSU Tetsuro
Development Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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KEMI Masayuki
Development Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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INAGAKI Satoru
Development Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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NAKATSUKA Toshio
Development Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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MATSUMOTO Hiroyoshi
Development Research Laboratories, Banyu Pharmaceutical Co., Ltd.
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Nakatsuka Toshio
Tsukuba Safety Assessment Laboratories Banyu Pharmaceutical Co. Ltd.
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Nakatsuka Toshio
Development Research Laboratories Banyu Pharmaceutical Co. Ltd.
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Matsumoto Hiroyoshi
Safety Assessment Development And Research Laboratories Banyu Pharmaceutical Co. Ltd.
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Matsumoto Hiroyoshi
Development Research Laboratories Banyu Pharmaceutical Co. Ltd.
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Kemi M
Tsukuba Safety Assessment Laboratories Banyu Pharmaceutical Co. Ltd.
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Kemi Masayuki
Development Research Laboratories Banyu Pharmaceutical Co. Ltd.
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Matsumoto Hitoshi
Department Of Preclinical Science Nippon Roche Research Center
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Komatsu Tetsuro
Development Research Laboratories Banyu Pharmaceutical Co. Ltd.
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Matsumoto Hiroyoshi
Development Res. Labs. Banyu Pharma. Co. Ltd.
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