Initial Arthritic Lesions Induced by Immunization with Type II Collagen in Lewis Rats
スポンサーリンク
概要
- 論文の詳細を見る
11Lewis rats were immunized with an intradermal injection of type II collagen to study the time course of arthritic lesions. Serum type II collagen antibody was detected 9 days after immunization. Increased paw volume in the hind limbs was noted on day 11. Histopathologically, proliferation of synovial lining cells was observed on day 11 and typical lesions similar to those of human rheumatoid arthritis were noted on day 18.
- 社団法人 日本実験動物学会の論文
著者
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TAKESHITA Masakazu
Marugo Research Service, Tanabe Seiyaku Co., Ltd.
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Takata Isao
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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FURUKAWA Osamu
Research and Development Center, Toshiba Corporation
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Takeshita Masakazu
Marugo Research Service Tanabe Seiyaku Co. Ltd.
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Furukawa Osamu
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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HINOUE Hiromi
Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
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Hinoue Hiromi
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
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Takeshita Masakazu
Marugo Research Service
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