Modification of Human T-Cell Responses by Altered Peptide Ligands: A New Approach to Antigen-specific Modification
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概要
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Human CD4+ T-cells recognize antigenic peptides in the context of human leukocyte antigen (HLA) class II molecules and produce various lymphokines to proliferate and activate other cells. It was once considered that the T-cell response is an all or nothing type event, but recent studies have clearly indicated that T-cells show many different types of activation in recognition of altered ligands for T-cell receptors (TCR). In this review, we summarize our recent findings on the human CD4+ T-cell response to altered peptide ligands (APL); peptides carrying single residue substitutions in antigenic peptides. We observed the following: 1) TCR antagonism for T-cell clones reactive to non-self or autoantigenic peptides, 2) partial activation (agonism) without cell proliferation, including production of lymphokines and increases in cell size, and in expression levels of several cell surface proteins or survival time in the absence of antigenic stimulus, 3) augmentation in cell proliferation and production of interferon-γ (IFN-γ) and granulocyte monocyte colony stimulating factor (GM-CSF), 4) augmentation of interleukin (IL)-12 production by antigen presenting cell (APC) and the subsequent augmented production of IFN-γ by T-cells. This information provides basic knowledge regarding the characteristics of T-cell recognition of antigens and the subsequent activation, and a novel method for modification of human T-cell responses by altered peptide ligands (APLs), as a possible candidate for antigen-specific immunopotentiating or immunosuppressive therapy against autoimmune diseases, allergies, infectious diseases and malignant tumors.(Internal Medicine 37: 804-817, 1998)
- 社団法人 日本内科学会の論文
著者
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YOKOMIZO Hiroshi
Div. Immunogenetics
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Chen Yu-zhen
Division Of Immunogenetics Department Of Neuroscience And Immunology Kumamoto University Graduate Sc
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KANAI TAKAYUKI
Divisional of Cardiology, Department of Internal Medicine, Kanto Rosai Hospital
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NISHIMURA Yasuharu
Division of Immunogenetics, Kumamoto University School of Medicine
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Kanai Takayuki
Division Of Immunogenetics Department Of Neuroscience And Immunology Kumamoto University Graduate Sc
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Kanai Takayuki
Department Of Immunogenetics Graduate School Of Medical Sciences Kumamoto University
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Matsushita Sho
Division Of Immunogenetics Department Of Neuroscience And Immunology Kumamoto University Graduate Sc
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Nishimura Yasuharu
Department Of Immunogenetics Graduate School Of Medical Sciences Kumamoto University
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Nishimura Yasuharu
Division Of Immunogenetics Department Of Neuroscience And Immunology Kumamoto University Graduate Sc
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Nishimura Yasuharu
The Division Of Immunogenetics Department Of Neuroscience And Immunology Kumamoto University Graduat
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Nishimura Yasuharu
Division Of Immunogenetics Department Of Neuroscience And Immunology Kumamoto University Graduate Sc
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YOKOMIZO Hiroshi
Division of Immunogenetics, Department of Neuroscience and Immunology, Kumamoto University Graduate
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MATSUOKA Takako
Division of Immunogenetics, Department of Neuroscience and Immunology, Kumamoto University Graduate
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Matsushita Sho
The Division Of Immunogenetics Department Of Neuroscience And Immunology Kumamoto University Graduat
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Matsuoka Takako
Division Of Immunogenetics Department Of Neuroscience And Immunology Kumamoto University Graduate Sc
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