Blood Pressure, Heart Rate and Motor Activity in 6 Inbred Rat Strains and Wild Rats (Rattus norvegicus): A Comparative Study
スポンサーリンク
概要
- 論文の詳細を見る
Inbreeding for many generations under optimal environmental conditions may have favoured the survival of alleles for blood pressure increase in phenotypically normotensive rat strains. To prove this hypothesis we measured telemetrically systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR) and motor activity (MA) in 6 inbred rat strains (BB, BN, LEW, DA, F344, WKY) and wild rats most probably possessing all of the alleles for normotension. For the first time it is shown that systolic blood pressure can significantly differ between normotensive inbred rat strains and that most probably some inbred rat strains will be characterised by a systolic blood pressure found in their progenitors, the wild rats. In addition, the typical night activity of rodents was not seen in 2 inbred rat strains. All findings together may be interpreted in the sense that most, if not all inbred rats strains have more or less disturbances in blood pressure, HR and/or MA and that there is most probably no "healthy" inbred rat strain available so that wild rats may be an alternative for crossing studies dissecting hypertension in particular and diseases in general.
- 社団法人 日本実験動物学会の論文
- 1999-10-01
著者
-
VAN DEN
Department of electrical engineering, Eindhoven University of Technology
-
KOVACS Peter
Department of Genetics, Cell and Immunobiology, Faculty of Medicine, Semmelweis University
-
Kovacs Peter
Department Of Genetics Cell And Immunobiology Faculty Of Medicine Semmelweis University
-
Kovacs Peter
Department Of Laboratory Animal Science At The Institute Of Pathophysiology University Of Greifswald
-
Van Den
Department Of Biology Laboratory For Molecular Plant Physiology Institute Of Botany And Microbiology
-
KLOTING Ingrid
Department of Laboratory Animal Science at the Institute of Pathophysiology, University of Greifswal
-
Kloting Ingrid
Department Of Laboratory Animal Science At The Institute Of Pathophysiology University Of Greifswald
-
Van Den
Department Of Laboratory Animal Science At The Institute Of Pathophysiology University Of Greifswald
関連論文
- Commutation of a Magnetically Levitated Planar Actuator with Moving-Magnets
- Changes in Laboratory Values and Their Relationship with Time After Rupture of an Abdominal Aortic Aneurysm
- Chromosome 1p loss evaluation in anaplastic oligodendrogliomas
- Bone marrow-derived mast cell differentiation is strongly reduced in histidine decarboxylase knockout, histamine-free mice
- Visual perceptual impairment in children at 5 years of age with perinatal haemorrhagic or ischaemic brain damage in relation to cerebral magnetic resonance imaging
- The variety of visual perceptual impairments in pre-school children with perinatal brain damage
- Immunohistochemical Detection of Salivary Agglutinin / gp-340 in Human Parotid, Submandibular, and Labial Salivary Glands
- Reply to comment on "Halitosis associated volatiles in breath of healthy subjects" by S. van den Velde et al. : J. Chromatogr. B 853 (2007) 54-61
- Halitosis associated volatiles in breath of healthy subjects
- Expansion of human γδ T cells after in vitro stimulation with Campylobacter jejuni
- Distribution of Interferon-Gamma Receptors in Normal and Psoriatic Skin
- Determination of cyclophosphamide metabolites by gas chromatography and thermionic specific detection Interindividual differences in hepatic biotransformation of cyclophosphamide in man in vitro
- Biomechanical Comparison of Sacroiliac Screw Techniques for Unstable Pelvic Ring Fractures
- Histatins Enhance Wound Closure with Oral and Non-oral Cells
- Alkylation of DNA by melphalan : investigation of capillary liquid chromatography-electrospray ionization tandem mass spectrometry in the study of the adducts at the nucleoside level
- Behavioral Graded Activity Following First-Time Lumbar Disc Surgery : 1-Year Results of a Randomized Clinical Trial
- Blood Pressure, Heart Rate and Motor Activity in 6 Inbred Rat Strains and Wild Rats (Rattus norvegicus): A Comparative Study
- The Effect of Structure on the Uptake of Polymeric Polypeptides by the Macrophage-like Cell Line J774
- Cloning, Characterization and Functional Analysis of a 1-FEH cDNA from Vernonia herbacea (Vell.) Rusby
- Familial Partial Epilepsy with Variable Foci in a Dutch Family : Clinical Characteristics and Confirmation of Linkage to Chromosome 22q
- Location and Limitation of Cellulose Production by Acetobacter xylinum Established from Oxygen Profiles
- Expression of Insulin-Like Growth Factor (IGF) Family Members in Porcine Pregnancy
- Modulation of Adenosine-Induced Responses in the Guinea-Pig Trachea During Long-Term Caffeine Treatment : Possible Role of Epithelium
- Detection of Odorous Compounds in Breath
- Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine
- Measurement of 25-OH-vitamin D in human serum using liquid chromatography tandem-mass spectrometry with comparision to radioimmunoassay and automated immunoassay
- Antigen-independent acquisition of MHC class II molecules by human T lymphocytes
- Selective usage of defined TCRBV genes in response to filarial antigens
- GC-MS analysis of breath odor compounds in liver patients
- Plasma citrulline measurement using UPLC tandem mass-spectrometry to determine small intestinal enterocyte pathology
- Longitudinal analysis of T cells responding to tetanus toxoid in healthy subjects as well as in pediatric patients after bone marrow transplantation : the identification of identical TCR-CDR3 regions in time suggests long-term stability of at least part o
- ${\mathcal D}\sb n$-Modules with Support on a Curve
- Cementum and Dentin in Hypophosphatasia
- ABDOMINAL PAIN AFTER MIGRATION OF A BILIARY ENDOPROSTHESIS
- Seizure Semiology of Occipital Lobe Epilepsy in Children
- Skewing of TCR V genes to CD4+ and CD8+ subsets of T lymphocytestes is not determined by amino acid composition of CDR3
- Can we improve outcome of congenital diaphragmatic hernia?
- Long-term follow-up of patients with recessive dystrophic epidermolysis bullosa in the Netherlands : Expansion of the mutation database and unusual phenotype-genotype correlations
- Transforming growth factor-β levels during second-intention healing are related to the different course of wound contraction in horses and ponies
- Risk of Aplastic Anemia in Patients Using Antiepileptic Drugs
- Bacterial load in relation to vacuum-assisted closure wound therapy : A prospective randomized trial
- Asthma, the ugly duckling of lung disease proteomics?
- Expression of Insulin-like Growth Factor (IGF) Family Members in Porcine Pregnancy
- A multiplex SNP assay for the dissection of human Y-chromosome haplogroup O representing the major paternal lineage in East and Southeast Asia
- Atypical hemolytic uremic syndrome and genetic aberrations in the complement factor H-related 5 gene
- Clinical Features Differ Substantially Between Caucasian and Asian Populations of Marfan Syndrome
- Cardiac herniation after operative management of lung cancer : a rare and dangerous complication