Comparison of Noradrenergic and Serotonergic Antidepressants in Reducing Immobility Time in the Tail Suspension Test
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概要
- 論文の詳細を見る
We examined the effects of two noradrenergic tricyclic antidepressants and two selective serotonin re-uptake inhibitors in the tail suspension test, with a suspension period of 30 min instead of the usual 10 min. Within the first 10 min, desipramine, nortriptyline and fluvoxamine significantly reduced the duration of immobility. Whereas desipramine and nortriptyline were also efficacious in the rest of the test period, fluvoxamine was not. Fluoxetine showed no significant effect throughout the study period. These results suggest that a prolonged tail suspension test results in functional changes in the noradrenergic and serotonergic systems and alters the sensitivity to antidepressants.
- 社団法人 日本薬理学会の論文
- 2001-03-01
著者
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Baba J
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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Baba Jun
Pharmaceutical Research Center Meiji Seika Kaisha Ltd
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Kosaka K
St. Marianna Medical Institute
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Kosaka Kenji
Department Of Psychiatry Yokohama City University School Of Medicine
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IMANISHI Taiichiro
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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FUJISHIRO Jun
Department of Psychiatry, Yokohama City University School of Medicine
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Kosaka Kenji
Department Of Physical Therapy Saitama Medical School Junior College
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Fujishiro Jun
Department Of Psychiatry Yokohama City University School Of Medicine
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Imanishi Taiichiro
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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Kosaka Kenji
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
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