Guinea Pig Histamine N-Methyltransferase: cDNA Cloning and mRNA Distribution
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概要
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We report here the isolation of histamine N-methyltransferase (HMT) cDNA from the guinea pig brain by the polymerase chain reaction on the basis of nucleotide sequences of rat and human counterparts. Guinea pig HMT consists of 292 amino acids, with homologies of 75.6% and 79.1% to rat and human HMT, respectively. Northern blotting analysis indicated that the 1.6-kb guinea pig HMT transcript was expressed at various levels in different tissues at the following relative abundance: jejunum, brain > lung, spleen, stomach > liver, kidney. HMT mRNA localized throughout the jejunum, and it was mainly expressed in epithelial cells and in Auerbachs plexus.
- 社団法人 日本薬理学会の論文
- 2001-01-01
著者
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TSUJIMURA Tohru
Department of Pathology, Hyogo College of Medicine
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Tsujimura Tohru
Department Of Pathology Hyogo College Of Medicine
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Tsujimura Tohru
Department Of Pathology I University Of Obihiro School Of Veterinary Medicine
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KITANAKA Junichi
Department of Pharmacology, Hyogo College of Medicine
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KITANAKA Nobue
Department of Pharmacology, University of Obihiro School of Veterinary Medicine
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KAKIHANA Michiko
Department of Pharmacology, University of Obihiro School of Veterinary Medicine
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Kitanaka Nobue
Department Of Pharmacologv Hyogo College Of Medicine
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Takemura Motohiko
Department Of Pharmacologv Hyogo College Of Medicine
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Kitanaka J
Department Of Pharmacologv Hyogo College Of Medicine
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Kitanaka Junichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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Kakihana Michiko
Department Of Pharmacology University Of Obihiro School Of Veterinary Medicine
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TERADA Nobuyuki
Pathology I, Hyogo College of Medicine
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TAKEMURA Motohiko
Pharmacology
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Kitanaka Junichi
Department of Pharmacologv, Hyogo College of Medicine
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