組織特異的に発現する遺伝子から見た分子の進化と組織の進化の関係〔英文〕 (木村資生先生古希祝賀献呈論文<特集>)

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概要

• 論文の詳細を見る

• In this paper, we reviewed our recent works on a possible link between molecular evolution and tissue evolution. The evolutionary rates of genes that are expressed tissue specifically were shown to differ widely to one another, depending on tissues: Brain specific genes evolve with significantly slower rate than immune specific genes. The tissue dependence of molecular evolutionary rate strongly suggests the presence of functional constraints against molecular changes from tissue level. A molecular phylogenetic analysis of tissue specific isoforms that are identical to one another in function, but differ only in tissue distribution revealed frequent gene duplications and rapid accumulations of amino acid substitutions during the early evolution of chordates, where rapid evolution at the tissue or organ levels is thought to have occurred. On the basis of functional constraints, a possible explanation for the correlation between evolution at the two levels was presented.

• 日本遺伝学会の論文
• 1994-10-25

著者

• 宮田 隆

  Department of Biophysics, Faculty of Science, Kyoto University

• Iwabe N

  Dept. Biophys. Grad. Sch. Of Sci. Kyoto Univ.

• KUMA Kei-ichi

  Department of Biophysics, Graduate School of Science, Kyoto University

• Nikoh N

  Kyoto Univ. Kyoto Jpn

• Kuma K

  Kyoto Univ. Kyoto Jpn

• Kuma Kei-ichi

  Department Of Biophysics Faculty Of Science Kyoto University

• MIYATA Takashi

  Department of Iron and Steel Engineering, Nagoya University

• Nikoh Naruo

  Department Of Biophysics Faculty Of Science Kyoto University

• Iwabe Naoyuki

  Department Of Biophysics Faculty Of Science Kyoto University

• Miyata Takashi

  Department Of Chemistry And Materials Engineering Kansai University

• Miyata Takashi

  Department Of Biophysics Faculty Of Science Kyoto University

• IWABE Naoyuki

  Department of Biology, Faculty of Science, Kyushu University

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