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Drug Safety Research And Development Pfizer Global Research And Development Nagoya Laboratories. Pfi | 論文
- Development of in vitro 3T3 Cell Neutral Red Uptake Phototoxicity Screening System(Test methods, Proceedings of the 32nd Annual Meeting)
- CHANGES OF MICRO-RNA EXPRESSION IN RAT LIVER TREATED BY ACETAMINOPHEN OR CARBON TETRACHLORIDE : REGULATING ROLE OF MICRO-RNA FOR RNA EXPRESSION
- EVALUATION OF HUMAN HEPATOCYTE CHIMERIC MICE AS A MODEL FOR TOXICOLOGICAL INVESTIGATION USING PANOMIC APPROACHES : EFFECT OF ACETAMINOPHEN ON THE EXPRESSION PROFILES OF PROTEINS AND ENDOGENOUS METABOLITES IN LIVER, PLASMA AND URINE
- GENOMIC CLUSTER AND NETWORK ANALYSIS FOR PREDICTIVE SCREENING FOR HEPATOTOXICITY
- PHYSICOCHEMICAL AND CELL-BASED APPROACH FOR EARLY SCREENING OF PHOSPHOLIPIDOSIS-INDUCING POTENTIAL
- INVESTIGATION OF PROTEOMIC BIOMARKERS IN IN VIVO HEPATOTOXICITY STUDY OF RAT LIVER : TOXICITY DIFFERENTIATION IN HEPATOTOXICANTS
- IN VIVO HEPATOTOXICITY STUDY OF RATS IN COMPARISON WITH IN VITRO HEPATOTOXICITY SCREENING SYSTEM
- Introduction of the in vivo Mini-tox study as an effective tool to improve confidence in safety in the early stage of drug development (2) Effects of atypical antipsychotics X(Test methods, Proceedings of the 32nd Annual Meeting)
- Investigation of protein expression induced by hepatotoxicants in rat hepatocytes cultures and livers(Proceedings of the 32nd Annual Meeting)
- Changes of sperm functions and epididymal gene expression in the rats treated with sulfasalazine for several days(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- Effect of aging on QT interval in guinea pigs(Circulatory system, Proceedings of the 32nd Annual Meeting)
- Comparison between in vitro- and in vivo-hepatotoxicity for the investigation of a hepatotoxicity screening system in primary cell cultures(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- PRACTICAL APPLICATION OF GUINEA PIG TELEMETRY SYSTEM FOR QT EVALUATION
- EFFECT OF AUTONOMIC NERVOUS FUNCTION ON QT INTERVAL IN DOGS
- IDENTIFICATION OF OXIDATIVE STRESS-RELATED PROTEINS FOR PREDICTIVE SCREENING OF HEPATOTOXICITY USING A PROTEOMIC APPROACH
- EFFECTS OF MALE REPRODUCTIVE TOXICANTS ON GENE EXPRESSION IN RAT TESTES
- PROTEIN EXPRESSION ANALYSIS OF RAT TESTES INDUCED TESTICULAR TOXICITY WITH SEVERAL REPRODUCTIVE TOXICANTS
- INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURES : WHAT BIOMARKERS WOULD NEED TO BE ADDRESSED TO ESTIMATE TOXICITY IN CONVENTIONAL AND NEW APPROACHES?
- P8-45 Estimation of exposure in toxicology study in discovery stage(BLOOD/TOXICOKINETICS/OTHERS-2)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P8-34 Usefulness of beam walking test for prediction of adverse effects, "vertigo and dizziness"(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)