Effects of the whole-body cryotherapy on a total antioxidative status and activities of some antioxidative enzymes in blood of patients with multiple sclerosis-preliminary study

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Objective. There is evidence that multiple sclerosis (MS) is not only characterizedby immune mediated inflammatory reactions but also by neurodegenerative processes.Neutralization of oxidative stress and excitotoxicity, might represent a therapeuticapproach to provide neuroprotection in MS. The purpose of this study was to comparechanges in total antioxidative status and activities of chosen antioxidative enzymes, suchas : SOD, CAT in erythrocytes of patients with MS before and after using WBCT with controlgroup. Materials and methods. 32 patients with multiple sclerosis (ICD10-G35) and20 healthy subjects were recruited for the study. The examined MS group (n=16) wastreated with a series of 10 daily exposures in a cryogenic chamber (2-3 min, from -120-to -110-) and program of exercises. The control MS group (n=16) had only exercises.Plasma TAS as well as SOD and CAT activities in erythrocytes were measured. Results.The level of TAS in MS patients was distinctly reduced compared to healthy subjects. Aftertwo weeks of WBCT treatment an increase of TAS in the whole examined group (p0,01) were observed in relation to control MS group. There was not increase of CuZnSODand CAT activities. Conclusion. Our results suggest positive antioxidant effects of WBCT asa short-term adjuvant treatment for patients suffered due to MS.