Induction of Phenylalanine and Tyrosine Oxidation in the Intoxicated Larva of the Silkworm, Bombyx mori L (Lepidoptera : Bombycidae), with MTMC (m-Tolyl-N-methylcarbamate)

概要

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Labeled phenylalanine or tyrosine administered to normal 5th instar larvae of the silkworm, Bombyx mori L (Lepidoptera : Bombycidae), was metabolized by sclerotization, that is, from phenylalanine to tyrosine, Dopa and Dopamine. Whereas the MTMC (m-tolyl-N-methylcarbamate) treatment altered the metabolism of aromatic amino acids in the silkworm, the interconversion between phenylalanine and tyrosine was almost completely blocked and 80% of the phenylalanine was converted into PLA (phenyllactic acid). The MTMC treatment induced formation of a significant amount of HPLA (p-hydroxyphenyllactic acid) from tyrosine, but it did not change the conversion of tyrosine into Dopa. Consequently, it was shown that MTMC treatment induced the deamination of phenylalanine and tyrosine, while it made normal and steady progress in sclerotization.
日本応用動物昆虫学会の論文
1982-05-25