APPLICATION OF GOLDSOLREACTION TO ENZYMOLOGICAL STUDIES
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It is well known that Zsigmondy (1) developed the preparation method of goldsol and investigated its physical and physiological properties. Later Lange (2-4) applied goldsolreaction to the cerebrospinal fluid, and it was introduced as Lange's Goldsolreaction. But the reaction mechanism of colloidal gold test is still unknown and is open to further study. The albumin which is essential element in cerebrospinal fluid has protecting action for goldsol, while the globulin acts coagulative for goldsol. If globulin is increased pathologically and albumin to globulin ratio (A/G) is decreased, colloid protecting action of cerebrospinal fluid may grow weak and the color of the goldsol suspension with cerebrospinal fluid changes in various degrees by increasing colloid lability. Since Maclagan <I>et al</I>. (5) examined extensively goldsolreaction with cerebrospinal fluid and blood after his research for conservation of goldsol, goldsolreaction has become to be utilized generally for clinical examination.<BR> Nishino (6) who applied the goldsolreaction to antigen-antibody reaction found that the color of the medium altered when the antigen was added to the system in which goldsol was protected by antiserum against sodium chloride. By the addition of antigen, the protecting action of antibody for goldsol was weakend and goldsol was coagulated.<BR> In the present paper, the author represents some results on the goldsolreaction applying to the enzymological studies.
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関連論文
- MONOAMINE OXIDASE ACTIVITY AND MITOCHONDRIAL STRUCTURE OF THE BRAIN
- APPLICATION OF GOLDSOLREACTION TO ENZYMOLOGICAL STUDIES