毛細血管壁力にかんする研究 (第2報)
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概要
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This report deals with how capillary wall holds its normal strength. Several bioflavonoids which work as capillary stabilizer were selected and the mechanism of their actions were investigated. By inhibiting the formation of vasodilating substance like acetylcholine and histamine, capillary resistance can be increased. Therefore in this report, the correlation between 1-histidine decarboxylase (H.D.) and bioflavonoid has been investigated. Clostridium Perfringens PB 6K was used as H.D., because I have found previously that it had strong histamine-forming enzyme.Ascorbic acid has shown the strongest inhibition rate against H.D. among capillary stabilizer and its use with bioflavonoid increased its effect largely and the same effect on capillary resistance was observed also in clinical application. Myricitrin and myricetin have had stronger inhibitory action than others and Rutin and quercetin have shown almost the same effect.Cortisone, ACTH, AC-17 and Parotin have been found to have no inhibitory action against it.β-diethylaminoethyl-myricitrin has shown nice effect upon capillary wall.The fact that the clinical effect of bioflavonoid is parallel with its H.D. inhibition rate suggests that such mechanism is held also in vivo.
- 社団法人 日本内科学会の論文