胃癌の増殖とCEA : I. 胃癌患者の血清CEA値とヌードマウス可移植性 II. ヌードマウス移植腫瘍の増殖と血清および組織CEA値の変動(Mini Symposium IX . 癌と腫瘍マーカー,ホルモン)

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We examined the correlation among preoperative serum carcioembryonic antigen (CEA) levels, staining properties of the tumors by CEA immunohistochemistry and the tumorigenicity of their xenografts in nude mice, in 28 partients with gastric cancer. Four human gastric cancer xenografts in nude mice, transplanted serially over 20 passages, were analyzed for tumor growth and associated levels of CEA in sera and tissues. I) Seven (25%) of 28 gastric cancer xenografts were tumorigenic in nude mice. The mean value of the serum CEA levels in the patients with tumorigenic neoplasms was 20.8 ng/ml, being significantly higher than that (1.4 ng/ml) with non-tumorigenic neoplasms (p<0.001). Twenty-five of the 28carcinomas (89 percent) were positive for CEA staining in their cancer cells by the ABC method and CEA localization correlated with tumor-igenicity (p<0.05). The mean post-operative survival of the patients with tumorigenic neoplasms was 9.4 months, wheras that with non-tumorigenic neoplasms was 15.6 months. II) Individual xenografts showed a positive correlation between tumor growth and serum CEA levels (p<0.001). A positive correlation was also observed between the tissue CEA staing in their cells by the ABC method and CEA level and tumor growth (p<0.05). Furthermore, the level of serum CEA closely paralleled that of tissue CEA (p<0.10). The deviation of the ratio of serum CEA level/tissue CEA level was constant among the xenografts (p<0.05), although the mean ratio differed slightly. These results suggest that serum CEA level closely correlated with tissue CEA level as well as tumor growth, and that the elevation of serum CEA is attributable to the tissue CEA level rater than tumor weight.

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