Percolation of Hydration Water as a Control of Protein Dynamics

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概要

• 論文の詳細を見る

• Protein cannot work without hydration water. In order to clarify the effect of hydration water on protein dynamics, incoherent neutron scattering and MD simulation are performed for the protein, staphylococcal nuclease. We found that the hydration level dependence of the onset of protein dynamical transition is correlated with the percolation transition of hydration water. In addition, hydration water dynamics change above the transition. The percolation of hydration water is essential to activate the anharmonic motions of a protein, which are responsible for protein function.

• Physical Society of Japanの論文
• 2010-08-15

著者

• Nakagawa Hiroshi

  Neutron Biophysics Group, Neutron Biology Research Center, Quantum Beam Science Direction, Japan Ato

• Hiroshi Nakagawa

  Neutron Biophysics Group, Molecular Biology Research Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319-1195, Japan

• Kataoka Mikio

  Neutron Biophysics Group, Molecular Biology Research Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319-1195, Japan

関連論文

• 1P038 Molecular simulation study of the origin of non-Gaussian behavior on the elastic incoherent neutron scattering from protein dynamics(1. Protein structure and dynamics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• Percolation of Hydration Water as a Control of Protein Dynamics

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