Subnanometer-resolution frequency modulation atomic force microscopy in liquid for biological applications

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概要

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• The spatial resolution and force sensitivity of frequency modulation atomic force microscopy (FM-AFM) in liquid have been dramatically improved in the last a few years. It is now possible to image individual atoms and molecules at a solid/liquid interface with a subnanometerscale resolution and a piconewton-order loading force. This capability enabled the direct visualization of hydration layers and mobile ions on a lipid bilayer and β-strands constituting an amyloid fibril. These striking results highlighted the significant potential of FM-AFM in biological research. Here, I summarize the technological innovation that brought about this progress and review biological applications of FM-AFM in liquid. © 2009 The Japan Society of Applied Physics.

• Japan Society of Applied Physics = JSAP 応用物理学会 / Institute of Pure and Applied Physicsの論文
• 2009-08-25

著者

• Fukuma Takeshi

  Frontier Science Organization Kanazawa University:presto Japan Science And Technology Agency

• Fukuma Takeshi

  Frontier Science Organization, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan

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• 3P-121 周波数変調原子間力顕微鏡によるモデル生体膜上に形成された水和層の分子分解能観察(水・水和/電解質,日本生物物理学会若手奨励賞選考会,若手招待講演,第46回日本生物物理学会年会)
• 1P-221 周波数変調AFMによるコレステロール-脂質二分子膜の分子分解能観察(生体膜/人工膜・構造物性,第46回日本生物物理学会年会)
• Subnanometer-resolution frequency modulation atomic force microscopy in liquid for biological applications

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