Subnanometer-resolution frequency modulation atomic force microscopy in liquid for biological applications
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概要
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The spatial resolution and force sensitivity of frequency modulation atomic force microscopy (FM-AFM) in liquid have been dramatically improved in the last a few years. It is now possible to image individual atoms and molecules at a solid/liquid interface with a subnanometerscale resolution and a piconewton-order loading force. This capability enabled the direct visualization of hydration layers and mobile ions on a lipid bilayer and β-strands constituting an amyloid fibril. These striking results highlighted the significant potential of FM-AFM in biological research. Here, I summarize the technological innovation that brought about this progress and review biological applications of FM-AFM in liquid. © 2009 The Japan Society of Applied Physics.
- Japan Society of Applied Physics = JSAP 応用物理学会 / Institute of Pure and Applied Physicsの論文
- 2009-08-25
著者
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Fukuma Takeshi
Frontier Science Organization Kanazawa University:presto Japan Science And Technology Agency
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Fukuma Takeshi
Frontier Science Organization, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
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- Subnanometer-resolution frequency modulation atomic force microscopy in liquid for biological applications